Please use this identifier to cite or link to this item:
|Title:||Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer|
|Author:||Archambault, Alexi N.|
Harrison, Tabitha A.
Bishop, D. Timothy
Chan, Andrew T.
Chang Claude, Jenny
Figueiredo, Jane C.
Gruber, Stephen B.
Gunter, Marc J.
Jenkins, Mark A.
Keku, Temitope O.
Marchand, Loïc Le
Moreno Aguado, Víctor
Newcomb, Polly A.
Parfrey, Patrick S.
Sakoda, Lori C.
Sandler, Robert S.
Slattery, Martha L.
Win, Aung Ko
Woods, Michael O.
Campbell, Peter T.
Zeleniuch Jacquotte, Anne
Liang, Peter S.
Hayes, Richard B.
Factors de risc en les malalties
Risk factors in diseases
|Publisher:||Oxford University Press (OUP)|
|Abstract:||Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods: Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Results: Early-onset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P = .04). Conclusion: In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1093/jncics/pkab029|
|It is part of:||JNCI Cancer Spectrum, 2021, vol. 5, num. 3|
|Appears in Collections:||Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))|
Articles publicats en revistes (Ciències Clíniques)
Files in This Item:
|pkab029.pdf||2.02 MB||Adobe PDF||View/Open|
This item is licensed under a Creative Commons License