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http://hdl.handle.net/2445/178991
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DC Field | Value | Language |
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dc.contributor.author | Ramchuran, Estelle J. | - |
dc.contributor.author | Pérez Guillén, Isabel | - |
dc.contributor.author | Bester, Linda A. | - |
dc.contributor.author | Khan, René | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Viñas, Miquel | - |
dc.contributor.author | Torre, Beatriz G. de la | - |
dc.date.accessioned | 2021-07-13T09:22:32Z | - |
dc.date.available | 2021-07-13T09:22:32Z | - |
dc.date.issued | 2021-06-10 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178991 | - |
dc.description.abstract | Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10060695 | - |
dc.relation.ispartof | Antibiotics, 2021, vol. 10, num. 6, p. 695 | - |
dc.relation.uri | https://doi.org/10.3390/antibiotics10060695 | - |
dc.rights | cc-by (c) Ramchuran, Estelle J. et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Síntesi en fase sólida | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Bacteris gramnegatius | - |
dc.subject.other | Solid-phase synthesis | - |
dc.subject.other | Peptides | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Gram-negative bacteria | - |
dc.title | Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 712745 | - |
dc.date.updated | 2021-07-13T09:22:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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712745.pdf | 2.93 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License