Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/179062
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DC Field | Value | Language |
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dc.contributor.author | Korkut, Anil | - |
dc.contributor.author | Zaidi, Sobia | - |
dc.contributor.author | Kanchi, Rupa S. | - |
dc.contributor.author | Rao, Shuyun | - |
dc.contributor.author | Gough, Nancy R. | - |
dc.contributor.author | Schultz, Andre | - |
dc.contributor.author | Li, Xubin | - |
dc.contributor.author | Lorenzi, Philip L. | - |
dc.contributor.author | Berger, Ashton C. | - |
dc.contributor.author | Robertson, Gordon | - |
dc.contributor.author | Kwong, Lawrence N. | - |
dc.contributor.author | Datto, Mike | - |
dc.contributor.author | Roszik, Jason | - |
dc.contributor.author | Ling, Shiyun | - |
dc.contributor.author | Ravikumar, Visweswaran | - |
dc.contributor.author | Manyam, Ganiraju | - |
dc.contributor.author | Rao, Arvind | - |
dc.contributor.author | Shelley, Simon | - |
dc.contributor.author | Liu, Yuexin | - |
dc.contributor.author | Ju, Zhenlin | - |
dc.contributor.author | Hansel, Donna | - |
dc.contributor.author | Velasco, Guillermo de | - |
dc.contributor.author | Pennathur, Arjun | - |
dc.contributor.author | Andersen, Jesper B. | - |
dc.contributor.author | O'Rourke, Colm J. | - |
dc.contributor.author | Ohshiro, Kazufumi | - |
dc.contributor.author | Jogunoori, Wilma | - |
dc.contributor.author | Nguyen, Bao-Ngoc | - |
dc.contributor.author | Li, Shulin | - |
dc.contributor.author | Osmanbeyoglu, Hatice U. | - |
dc.contributor.author | Ajani, Jaffer A. | - |
dc.contributor.author | Mani, Sendurai A. | - |
dc.contributor.author | Houseman, Andres | - |
dc.contributor.author | Wiznerowicz, Maciej | - |
dc.contributor.author | Chen, Jian | - |
dc.contributor.author | Gu, Shoujun | - |
dc.contributor.author | Ma, Wencai | - |
dc.contributor.author | Zhang, Jiexin | - |
dc.contributor.author | Tong, Pan | - |
dc.contributor.author | Cancer Genome Atlas Research Network | - |
dc.date.accessioned | 2021-07-14T12:17:04Z | - |
dc.date.available | 2021-07-14T12:17:04Z | - |
dc.date.issued | 2018-10-24 | - |
dc.identifier.issn | 2405-4712 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179062 | - |
dc.description.abstract | We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and regulators of TGF-β signaling, we found at least one genomic alteration (mutation, homozygous deletion, or amplification) in 39% of samples, with highest frequencies in gastrointestinal cancers. We identified mutation hotspots in genes that encode TGF-β ligands (BMP5), receptors (TGFBR2, AVCR2A, and BMPR2), and Smads (SMAD2 and SMAD4). Alterations in the TGF-β superfamily correlated positively with expression of metastasis-associated genes and with decreased survival. Correlation analyses showed the contributions of mutation, amplification, deletion, DNA methylation, and miRNA expression to transcriptional activity of TGF-β signaling in each cancer type. This study provides a broad molecular perspective relevant for future functional and therapeutic studies of the diverse cancer pathways mediated by the TGF-β superfamily. | - |
dc.format.extent | 4369999579 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://www.cell.com/cell-systems/fulltext/S2405-4712(18)30357-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405471218303570 | - |
dc.relation.ispartof | Cell Systems, 2018, vol. 7, num. 4, p. 422-437.e7 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2018 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Transducció de senyal cel·lular | - |
dc.subject.classification | Factors de creixement | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Mutation (Biology) | - |
dc.subject.other | Genetics | - |
dc.subject.other | Cellular signal transduction | - |
dc.subject.other | Growth factors | - |
dc.subject.other | Cancer | - |
dc.title | A Pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the tgf-β superfamily | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 687423 | - |
dc.date.updated | 2021-07-14T12:17:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30268436 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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687423.pdf | 10.91 MB | Adobe PDF | View/Open |
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