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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179068
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dc.contributor.authorMorales, Paula-
dc.contributor.authorNavarro Brugal, Gemma-
dc.contributor.authorGómez-Autet, Marc-
dc.contributor.authorRedondo, Laura-
dc.contributor.authorFernández-Ruiz, Javier-
dc.contributor.authorPérez-Benito, Laura-
dc.contributor.authorCordomí, Arnau-
dc.contributor.authorPardo, Leonardo-
dc.contributor.authorFranco Fernández, Rafael-
dc.contributor.authorJagerovic, Nadine-
dc.date.accessioned2021-07-15T05:49:44Z-
dc.date.available2021-11-09T06:10:21Z-
dc.date.issued2020-11-09-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/2445/179068-
dc.description.abstractSingle chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis.-
dc.format.extent4 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/chem.202003389-
dc.relation.ispartofChemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842-
dc.relation.urihttps://doi.org/10.1002/chem.202003389-
dc.rights(c) Wiley-VCH, 2020-
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)-
dc.subject.classificationReceptors cel·lulars-
dc.subject.classificationProteïnes G-
dc.subject.classificationInteracció cel·lular-
dc.subject.classificationCànnabis-
dc.subject.otherCell receptors-
dc.subject.otherG Proteins-
dc.subject.otherCell interaction-
dc.subject.otherCannabis-
dc.titleDiscovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec709677-
dc.date.updated2021-07-15T05:49:45Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid32794211-
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Bioquímica i Fisiologia)

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