Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/179068
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DC Field | Value | Language |
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dc.contributor.author | Morales, Paula | - |
dc.contributor.author | Navarro Brugal, Gemma | - |
dc.contributor.author | Gómez-Autet, Marc | - |
dc.contributor.author | Redondo, Laura | - |
dc.contributor.author | Fernández-Ruiz, Javier | - |
dc.contributor.author | Pérez-Benito, Laura | - |
dc.contributor.author | Cordomí, Arnau | - |
dc.contributor.author | Pardo, Leonardo | - |
dc.contributor.author | Franco Fernández, Rafael | - |
dc.contributor.author | Jagerovic, Nadine | - |
dc.date.accessioned | 2021-07-15T05:49:44Z | - |
dc.date.available | 2021-11-09T06:10:21Z | - |
dc.date.issued | 2020-11-09 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179068 | - |
dc.description.abstract | Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/chem.202003389 | - |
dc.relation.ispartof | Chemistry-A European Journal, 2020, vol. 26, num. 68, p. 15839-15842 | - |
dc.relation.uri | https://doi.org/10.1002/chem.202003389 | - |
dc.rights | (c) Wiley-VCH, 2020 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.classification | Interacció cel·lular | - |
dc.subject.classification | Cànnabis | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | G Proteins | - |
dc.subject.other | Cell interaction | - |
dc.subject.other | Cannabis | - |
dc.title | Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor** | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 709677 | - |
dc.date.updated | 2021-07-15T05:49:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32794211 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
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709677.pdf | 1.75 MB | Adobe PDF | View/Open |
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