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DC Field | Value | Language |
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dc.contributor.author | Suarez Lledó, Ana | - |
dc.contributor.author | Leiva Badosa, Elisabet | - |
dc.contributor.author | Llop Talaverón, Josep Manuel | - |
dc.contributor.author | Fernández Alvarez, Mónica | - |
dc.contributor.author | Farrán Teixidor, Leandre | - |
dc.contributor.author | Miró Martín, Mónica | - |
dc.contributor.author | Virgili Casas, Nuria | - |
dc.contributor.author | Creus Costas, Glòria | - |
dc.contributor.author | Bas Minguet, Jordi | - |
dc.contributor.author | Poyatos Canton, Elisabet | - |
dc.contributor.author | Navarro Velazquez, Sergio | - |
dc.contributor.author | Badia Tahull, Maria Bella | - |
dc.date.accessioned | 2021-07-15T08:38:02Z | - |
dc.date.available | 2021-07-15T08:38:02Z | - |
dc.date.issued | 2021-06-25 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179092 | - |
dc.description.abstract | Introduction: Esophagectomy is a major surgery with a high degree of catabolic and post-surgical inflammatory response accompanied by high morbidity and significant mortality. Post-surgical nutritional support via enteral administration of omega-3 fatty acids has been seen to be effective although its bad tolerance. There are few clinical trials with parenteral omega-3 fatty acids in these patients. We propose to investigate the effect of combining a parenteral fish oil lipid emulsion with the standard enteral nutrition (EN) support. Materials and methods: Prospective, single-center, randomized, double-blind study in esophagectomized patients, and treated after surgery with parenteral lipid emulsions of omega-3 fatty acids or a mixture of omega-6 long-chain triglycerides/short-chain triglycerides 50%. These emulsions will be added to the standard nutritional support in continuous infusion until 5 days of treatment have been completed. Patients will be randomized 1:1:1 in Group A receiving 0.4 g/kg/d of fish-oil lipid emulsion and 0.4 g/kg/d of a lipid emulsion mixture of omega-6 long-chain fatty acids (LCT) plus medium-chain fatty acids (MCT) (total dose of 0.8 g/kg/d of lipid emulsion); Group B receiving 0.8 g/kg/d of fish oil lipid emulsion and Group C receiving 0.8 g/kg/d of LCT/MCT emulsion. The main objective is to determine whether 5 days administration of intravenous omega-3 fatty acid lipid emulsion is effective in normalizing interleukin-6 levels compared with LCT/MCT emulsions, and whether a 0.8 g/kg/d dose is more effective than 0.4 g/kg/d. Secondary outcomes include other inflammatory markers such as C-reactive protein, tumor necrosis factor alpha and interleukin-10, and parameters of morbidity, safety, nutrition and mortality. Samples will be collected at the time when surgery is indicated and on days 0, 1, 3, 5 and 21 to determine inflammatory, nutritional, hepatic and safety parameters. In addition, clinical follow-up will be continued throughout the hospital admision and up to 1 year after surgery. Discussion: Studies of omega-3 fatty acids administered parenterally in esophagectomized patients are scarce. This study proposes to investigate the effect of combining fish-oil lipid emulsions administered parenterally with EN support. Potential benefits include fast incorporation of lipids to the cellular membranes and to the inflammatory cascade, and the use of only 1 pharmaconutrient. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000026426 | - |
dc.relation.ispartof | Medicine, 2021, vol. 100, num. 25, p. e26426 | - |
dc.relation.uri | https://doi.org/10.1097/MD.0000000000026426 | - |
dc.rights | cc by (c) Suarez Lledó, Ana et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.classification | Període postoperatori | - |
dc.subject.classification | Olis de peix | - |
dc.subject.classification | Alimentació parenteral | - |
dc.subject.classification | Malalties de l'esòfag | - |
dc.subject.other | Clinical trials | - |
dc.subject.other | Postoperative period | - |
dc.subject.other | Fish oils | - |
dc.subject.other | Parenteral feeding | - |
dc.subject.other | Esophagus diseases | - |
dc.title | Clinical, randomized, double blind clinical trial to study the effect of parenteral supplementation with fish oil emulsion in the nutritional support in esophagectomized patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publshedVersion | - |
dc.date.updated | 2021-07-15T08:13:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34160431 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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medi-100-e26426.pdf | 500.74 kB | Adobe PDF | View/Open |
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