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Title: Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies
Author: Fernández Costa, Juan M.
Fernández Garibay, Xiomara
Velasco Mallorquí, Ferran
Ramón Azcón, Javier
Keywords: Materials biomèdics
Enginyeria de teixits
Distròfia muscular
Biomedical materials
Tissue engineering
Muscular dystrophy
Issue Date: 10-Feb-2021
Publisher: SAGE journals
Abstract: Muscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this review, we summarize the recent technological advances in skeletal muscle tissue engineering. We identify several ground-breaking techniques to fabricate in vitro bioartificial muscles. Accumulating evidence shows that scaffold-based tissue engineering provides topographical cues that enhance the viability and maturation of skeletal muscle. Functional bioartificial muscles have been developed using human myoblasts. These tissues accurately responded to electrical and biological stimulation. Moreover, advanced drug screening tools can be fabricated integrating these tissues in electrical stimulation platforms. However, more work introducing patient-derived cells and integrating these tissues in microdevices is needed to promote the clinical translation of bioengineered skeletal muscle as preclinical tools for muscular dystrophies.
Note: Reproducció del document publicat a:
It is part of: Journal of Tissue Engineering, 2021, vol. 12
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ISSN: 2041-7314
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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