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http://hdl.handle.net/2445/179256
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DC Field | Value | Language |
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dc.contributor.author | Leeman, Annemiek | - |
dc.contributor.author | Pino Saladrigues, Marta del | - |
dc.contributor.author | Marimon, Lorena | - |
dc.contributor.author | Torné Bladé, Aureli | - |
dc.contributor.author | Ordi, Jaume | - |
dc.contributor.author | Ter Harmsel, Bram | - |
dc.contributor.author | Meijer, Chris J. L. M. | - |
dc.contributor.author | Jenkins, David | - |
dc.contributor.author | Van Kemenade, Folkert J. | - |
dc.contributor.author | Quint, Wim | - |
dc.date.accessioned | 2021-07-21T08:46:31Z | - |
dc.date.available | 2021-07-21T08:46:31Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179256 | - |
dc.description.abstract | Cervical screening aims to identify women with high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 2-3 (HSIL/CIN2-3) or invasive cervical cancer (ICC). Identification of women with severe premalignant lesions or ICC (CIN3+) could ensure their rapid treatment and prevent overtreatment. We investigated high-risk human papillomavirus (hrHPV) detection with genotyping and methylation of FAM19A4/miR124-2 for detection of CIN3+ in 538 women attending colposcopy for abnormal cytology. All women had an additional cytology with hrHPV testing (GP5+/6+-PCR-EIA+), genotyping (HPV16/18, HPV16/18/31/45), and methylation analysis (FAM19A4/miR124-2) and at least one biopsy. CIN3+ detection was studied overall and in women <30 (n = 171) and ≥30 years (n = 367). Positivity for both rather than just one methylation markers increased in CIN3, and all ICC was positive for both. Overall sensitivity and specificity for CIN3+ were, respectively, 90.3% (95%CI 81.3-95.2) and 31.8% (95%CI 27.7-36.1) for hrHPV, 77.8% (95%CI 66.9-85.8) and 69.3% (95%CI 65.0-73.3) for methylation biomarkers and 93.1% (95%CI 84.8-97.0) and 49.4% (95%CI 44.8-53.9) for combined HPV16/18 and/or methylation positivity. For CIN3, hrHPV was found in 90.9% (95%CI 81.6-95.8), methylation positivity in 75.8% (95%CI 64.2-84.5) and HPV16/18 and/or methylation positivity in 92.4% (95%CI 83.5-96.7). In women aged ≥30, the sensitivity of combined HPV16/18 and methylation was increased (98.2%, 95%CI 90.6-99.7) with a specificity of 46.3% (95%CI 40.8-51.9). Combination of HPV16/18 and methylation analysis was very sensitive and offered improved specificity for CIN3+, opening the possibility of rapid treatment for these women and follow-up for women with potentially regressive, less advanced, HSIL/CIN2 lesions. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/ijc.31787 | - |
dc.relation.ispartof | International Journal of Cancer, 2019, vol. 144, num. 1, p. 160-168 | - |
dc.relation.uri | https://doi.org/10.1002/ijc.31787 | - |
dc.rights | (c) Union for International Cancer Control (UICC), 2019 | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Medicina preventiva | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Preventive medicine | - |
dc.title | Reliable identification of women with CIN3+ using hrHPV genotyping and methylation markers in a cytology-screened referral population. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 687933 | - |
dc.date.updated | 2021-07-21T08:46:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30098013 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (ISGlobal) |
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687933.pdf | 311.01 kB | Adobe PDF | View/Open |
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