Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/179296
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ibáñez Sanz, Gemma | - |
dc.contributor.author | Milà, Núria | - |
dc.contributor.author | Vidal Lancis, Maria Carmen | - |
dc.contributor.author | Rocamora, Judith | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Sanz Pamplona, Rebeca | - |
dc.contributor.author | García Martínez, Montserrat | - |
dc.contributor.author | MSIC-SC Research Group | - |
dc.date.accessioned | 2021-07-22T10:06:25Z | - |
dc.date.available | 2021-07-22T10:06:25Z | - |
dc.date.issued | 2021-06-30 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179296 | - |
dc.description.abstract | Introduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group). Material and methods Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (<= 24 months); a non-uptake cancer was a cancer in subjects who declined screening. Results A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs. Conclusion CRC screening with the FIT was associated with a significant reduction in CRC mortality. | ca |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Public Library of Science (PLoS) | ca |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0253369 | - |
dc.relation.ispartof | PLOS ONE, 2021, vol.16, num. 6, p. e0253369 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0253369 | - |
dc.rights | cc by (c) Ibáñez Sanz, Gemma et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Cribratge | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Medical screening | - |
dc.subject.other | Mortality | - |
dc.title | Positive impact of a faecal-based screening programme on colorectal cancer mortality risk | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-07-22T09:02:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
dc.identifier.pmid | 34191813 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
journal.pone.0253369.pdf | 1.11 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License