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Title: Epigenetic differences arise during the lifetime of monozygotic twins
Author: Fraga, Mario F.
Ballestar Tarín, Esteban
Paz, Maria F.
Ropero, Santiago
Setién, Fernando
Ballester Palacios, M. L. (Maria Lluïsa)
Heine-Suñer, Damia
Cigudosa, Juan Cruz
Urioste, Miguel
Benitez, Javier
Boix-Chornet, Manuel
Sánchez-Aguilera, Abel
Ling, Charlotte
Carlsson, Emma
Poulsen, Pernille
Vaag, Allan
Stephan, Zarko
Spector, Tim D.
Wu, Yue-Zhong
Plass, Christoph
Esteller, Manel
Keywords: ADN
Expressió gènica
Gene expression
Issue Date: 26-Jul-2005
Publisher: National Academy of Sciences
Abstract: Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.
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It is part of: Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 30, p. 10604-10609
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ISSN: 0027-8424
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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