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Title: | Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID |
Author: | Calderón Parra, Jorge Muiño Míguez, Antonio Bendala Estrada, Alejandro David Ramos Martínez, Antonio Muñez Rubio, Elena Fernández Carracedo, Eduardo Tejada Montes, Javier Rubio-Rivas, Manuel Arnalich Fernández, Francisco Beato Pérez, José Luis García Bruñén, Jose Miguel Corral-Beamonte, Esther del Pesqueira Fontan, Paula Maria Carmona, Maria Del Mar Fernández-Madera Martínez, Rosa González García, Andrés Salazar Mosteiro, Cristina Tuñón de Almeida, Carlota González Moraleja, Julio Deodati, Francesco Martín Escalante, María Dolores Asensio Tomás, María Luisa Gómez Huelgas, Ricardo Casas Rojo, José Millán Núñez-Cortés, Jesús For The Semi-covid-19 Network |
Keywords: | Atenció farmacèutica COVID-19 Pharmacy practice COVID-19 |
Issue Date: | 11-May-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background: Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to increased complications, including antibacterial resistance. We aim to analyze risk factors for inappropriate antibiotic prescription in these patients and describe possible complications arising from their use. Methods: The SEMI-COVID-19 Registry is a multicenter, retrospective patient cohort. Patients with antibiotic were divided into two groups according to appropriate or inappropriate prescription, depending on whether the patient fulfill any criteria for its use. Comparison was made by means of multilevel logistic regression analysis. Possible complications of antibiotic use were also identified. Results: Out of 13,932 patients, 3047 (21.6%) were prescribed no antibiotics, 6116 (43.9%) were appropriately prescribed antibiotics, and 4769 (34.2%) were inappropriately prescribed antibiotics. The following were independent factors of inappropriate prescription: February-March 2020 admission (OR 1.54, 95%CI 1.18-2.00), age (OR 0.98, 95%CI 0.97-0.99), absence of comorbidity (OR 1.43, 95%CI 1.05-1.94), dry cough (OR 2.51, 95%CI 1.94-3.26), fever (OR 1.33, 95%CI 1.13-1.56), dyspnea (OR 1.31, 95%CI 1.04-1.69), flu-like symptoms (OR 2.70, 95%CI 1.75-4.17), and elevated C-reactive protein levels (OR 1.01 for each mg/L increase, 95% CI 1.00-1.01). Adverse drug reactions were more frequent in patients who received ANTIBIOTIC (4.9% vs 2.7%, p < .001). Conclusion: The inappropriate use of antibiotics was very frequent in COVID-19 patients and entailed an increased risk of adverse reactions. It is crucial to define criteria for their use in these patients. Knowledge of the factors associated with inappropriate prescribing can be helpful. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0251340 |
It is part of: | PLOS ONE, 2021, vol. 16, num. 5 |
URI: | http://hdl.handle.net/2445/179329 |
Related resource: | https://doi.org/10.1371/journal.pone.0251340 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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