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Title: Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
Author: Sánchez Benavides, Gonzalo
Suárez Calvet, Marc
Milà Alomà, Marta
Arenaza Urquijo, Eider M.
Grau Rivera, Oriol
Operto, Grégory
Gispert, Juan Domingo
Vilor Tejedor, Natalia
Sala Vila, Aleix
Crous Bou, Marta
González de Echávarri, José Maria
Minguillon, Carolina
Fauria, Karine
Simon, Maryline
Kollmorgen, Gwendlyn
Zetterberg, Henrik
Blennow, Kaj
Molinuevo, José Luis
the ALFA Study
Keywords: Marcadors bioquímics
Hipocamp (Cervell)
Malalties neurodegeneratives
Biochemical markers
Hippocampus (Brain)
Neurodegenerative Diseases
Issue Date: 1-Jul-2021
Publisher: Elsevier BV
Abstract: Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-β (Aβ) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Linear models accounting for covariates (age, gender, and mood) were used to test the association between CSF NfL and SCD status, and between CSF NfL and bilateral hippocampal volumes. Interactions with Aβ were also explored. Individuals with SCD had higher CSF NfL and lower CSF Aβ42/40 than Controls. There was a significant interaction between SCD and CSF-Aβ42/40 levels. Stratified analyses showed a significant association between SCD and NfL only in Aβ+ individuals. Higher CSF NfL was significantly associated with lower hippocampal volume specifically in Aβ+ individuals with SCD. The presence of SCD in Aβ+ individuals may represent an early symptom in the Alzheimer's continuum related to incipient neurodegeneration.
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It is part of: Neurobiology of Aging, 2021, vol. 104, p. 24-31
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ISSN: 0197-4580
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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