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Title: Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort.
Author: Jesús, Silvia
Labrador Espinosa, M. A
Adarmes Gómez, Astrid
Méndel Del Barrio, C.
Martínez Castrillo, J. C.
Alonso Cánovas, Araceli
Sánchez Alonso, P.
Novo Ponte, S.
Alonso Losada, Maria Gema
López Ariztegui, Nuria
Segundo Rodríguez, J. C.
Morales, M. I.
Gastón, I.
Lacruz Bescos, F.
Clavero Ibarra, P.
Kulisevsky, Jaime
Pagonabarraga, Javier
Pascual Sedano, Berta
Martínez Martín, Pablo
Santos García, D.
Mir, Pablo
Keywords: Malaltia de Parkinson
Parkinson's disease
Issue Date: 9-Oct-2020
Publisher: Nature Publishing Group
Abstract: The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.
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It is part of: Scientific Reports, 2020, vol. 10, num. 1, p. 16893
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)

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