Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/179620
Title: | Evolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era. |
Author: | Videla, Sebas Sirera, Guillem López-Blázquez, Raquel Llatjos, Mariona Tarrats, Antoni Castellà, Eva Grane, Nuria Alcalde, Carme Tural, Cristina Rey-Joly, Celestino Clotet, Bonaventura, 1953- |
Keywords: | Antiretrovirals Coll uterí VIH (Virus) Càncer Antiretroviral agents Cervix uteri HIV (Viruses) Cancer |
Issue Date: | 1-Aug-2007 |
Publisher: | Mary Ann Liebert |
Abstract: | The influence of HAART on the evolution to cervical squamous intraepithelial lesions (SIL) among HIV(+) women with a normal cytological test in the HAART era was studied. A retrospective cohort study (1997-2005) of HIV-infected women treated with HAART was conducted. Those with a normal cervical cytology (Papanicolaou test) and at least one subsequent test were included. Survival (time until diagnosis of SIL), univariate, and multivariate analyses were performed. A total of 133 HIV-infected patients treated with HAART were included. The incidence of SIL was 35% (47 patients). SIL was diagnosed in 36 of 110 (33%) patients with a baseline and final immunological status of >200 CD4 cells/microl and in 6 of 9 (67%) patients with a baseline and final immunological status of < or =200 CD4 (OR: 0.24, 95% CI: 0.06-1.03, p = 0.041). SIL was diagnosed in 10 of 60 (17%) patients with an undetectable baseline and final HIV viral load and in 36 of 70 (51%) patients with a detectable HIV viral load (OR: 0.19, 95% CI: 0.07-0.46, p < 0.001). A high incidence of SIL (cancer precursor lesions) was observed among HIV(+) women without a background of cervical pathology. The effect of HAART on the control of HIV replication and of immunological status (>200 CD4) through the follow-up was associated with a reduction of SIL. |
Note: | Reproducció del document publicat a: https://doi.org/10.1089/aid.2006.0293 |
It is part of: | Aids Research and Human Retroviruses, 2007, vol. 23, num. 8, p. 965-971 |
URI: | http://hdl.handle.net/2445/179620 |
Related resource: | https://doi.org/10.1089/aid.2006.0293 |
ISSN: | 0889-2229 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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