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Title: Annexins animal models - from fundamental principles to translational research
Author: Grewal, Thomas
Rentero Alfonso, Carles
Enrich Bastús, Carles
Wahba, Mohamed
Raabe, Carsten A.
Rescher, Ursula
Keywords: Investigació mèdica
Experimentació animal
Medicine research
Animal experimentation
Issue Date: 26-Mar-2021
Publisher: MDPI
Abstract: Routine manipulation of the mouse genome has become a landmark in biomedical research. Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into the clinical setting. The annexins, a family of closely related calcium (Ca2+)- and lipid-binding proteins, are found at various intra- and extracellular locations, and interact with a broad range of membrane lipids and proteins. Their impacts on cellular functions has been extensively assessed in vitro, yet annexin-deficient mouse models generally develop normally and do not display obvious phenotypes. Only in recent years, studies examining genetically modified annexin mouse models which were exposed to stress conditions mimicking human disease often revealed striking phenotypes. This review is the first comprehensive overview of annexin-related research using animal models and their exciting future use for relevant issues in biology and experimental medicine.
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It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 7
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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