Please use this identifier to cite or link to this item:
|Annexins animal models - from fundamental principles to translational research
Rentero Alfonso, Carles
Enrich Bastús, Carles
Raabe, Carsten A.
|Routine manipulation of the mouse genome has become a landmark in biomedical research. Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into the clinical setting. The annexins, a family of closely related calcium (Ca2+)- and lipid-binding proteins, are found at various intra- and extracellular locations, and interact with a broad range of membrane lipids and proteins. Their impacts on cellular functions has been extensively assessed in vitro, yet annexin-deficient mouse models generally develop normally and do not display obvious phenotypes. Only in recent years, studies examining genetically modified annexin mouse models which were exposed to stress conditions mimicking human disease often revealed striking phenotypes. This review is the first comprehensive overview of annexin-related research using animal models and their exciting future use for relevant issues in biology and experimental medicine.
|Reproducció del document publicat a: https://doi.org/10.3390/ijms22073439
|It is part of:
|International Journal of Molecular Sciences, 2021, vol. 22, num. 7
|Appears in Collections:
|Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
This item is licensed under a Creative Commons License