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Title: | HLA association with the susceptibility to anti-synthetase syndrome |
Author: | Remuzgo Martínez, Sara Atienza Mateo, Belén Ocejo Vinyals, J. Gonzalo Pulito Cueto, Verónica Prieto Peña, Diana Genre, Fernanda Marquez, Ana Llorca, Javier Mora Cuesta, Víctor M. Iturbe Fernández, David Riesco, Laura Ortego Centeno, Norberto Pérez Gómez, Nair Mera, Antonio Martínez Barrio, Julia López Longo, Francisco Javier Lera Gómez, Leticia Moriano, Clara Díez, Elvira Tomero, Eva Calvo Alén, Jaime Romero Bueno, Fredeswinda Sanchez Pernaute, Olga Nuño, Laura Bonilla, Gema Grafia, Ignacio Prieto González, Sergio Narváez García, Francisco Javier Trallero Araguas, Ernesto Selva O’Callaghan, Albert Gualillo, Oreste Martín, Javier Cavagna, Lorenzo Castañeda, Santos Cifrian, José M. Renzoni, Elisabetta A. López Mejías, Raquel González Gay, Miguel A. |
Keywords: | Malalties autoimmunitàries Autoanticossos Malalties hereditàries Autoimmune diseases Genetic diseases Autoantibodies |
Issue Date: | 1-May-2021 |
Publisher: | Elsevier BV |
Abstract: | Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P=1.56E-09, odds ratio-OR [95% confidence interval-CI]=2.54 [1.84-3.50] and 21.4% versus 5.5%, P=18.95E-18, OR [95% CI]=4.73 [3.18-7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P=0.0003, OR [95% CI]=0.48 [0.31-0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P=0.001, OR [95% CI]=2.54 [1.39-4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions: Our results support the association of the HLA complex with the susceptibility to ASSD. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jbspin.2020.105115 |
It is part of: | Joint Bone Spine, 2021, vol. 88, num. 3, p. 105115 |
URI: | http://hdl.handle.net/2445/179746 |
Related resource: | https://doi.org/10.1016/j.jbspin.2020.105115 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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