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Title: Comparison of two-drug combinations, amikacin/tigecycline/imipenem and amikacin/tigecycline/clarithromycin against Mycobacteroides abscessus subsp. abscessus using the in vitro time-kill assay
Author: Portell Buj, Elena
Bonet Rossinyol, Queralt
López Gavín, Alexandre
Roman, Angely
Fernández Pittol, Mariana José
Tudó i Vilanova, Griselda
González Martín, Julián
Keywords: Malalties del pulmó
Farmacologia respiratòria
Pulmonary diseases
Pulmonary pharmacology
Issue Date: 8-Jan-2021
Publisher: Springer Nature
Abstract: Nontuberculous mycobacteria include 198 mycobacterial species. Among these, Mycobacteroides abscessus is a rapidly growing mycobacteria that causes lung and skin infections. M. abscessus lung infections are difficult to treat due to the high levels of resistance to several classes of antibiotics. The current treatment is based on combining at least two or three antibiotics. However, treatment outcomes remain very poor. The objective was to compare the in vitro activity of amikacin, tigecycline, imipenem, and clarithromycin, alone and in two different three-drug combinations (amikacin/tigecycline/imipenem and amikacin/tigecycline/clarithromycin) against seven M. abscessus subsp. abscessus clinical isolates using the time-kill assay. The two combinations showed greater activity than the antibiotics tested individually. Even though both combinations showed similar activity as well as no antagonistic activity, the combination including imipenem could not be an alternative treatment against M. abscessus subsp. abscessus lung infections caused by clarithromycin susceptible isolates. However, this combination could be considered against clarithromycin resistant isolates. Future studies are necessary to confirm this hypothesis.
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It is part of: Journal of Antibiotics, 2021, vol. 74, p. 285-290
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ISSN: 0021-8820
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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