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http://hdl.handle.net/2445/179783| Title: | A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars |
| Author: | Terrazas Martínez, Montserrat Aviñó Andrés, Anna Siddiqui, Maqbool A. Marquez, Victor E. Eritja i Casadellà, Ramon |
| Keywords: | RNA Nucleòsids Estructura molecular RNA Nucleosides Molecular structure |
| Issue Date: | 9-May-2011 |
| Publisher: | American Chemical Society |
| Abstract: | An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/ol200909j |
| It is part of: | Organic Letters, 2011, vol. 13, num. 11, p. 2888-2891 |
| URI: | http://hdl.handle.net/2445/179783 |
| Related resource: | https://doi.org/10.1021/ol200909j |
| ISSN: | 1523-7060 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 713432.pdf | 1.26 MB | Adobe PDF | View/Open |
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