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DC Field | Value | Language |
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dc.contributor.author | Santos García, D. | - |
dc.contributor.author | De Deus, Teresa | - |
dc.contributor.author | Cores, Carlos | - |
dc.contributor.author | Canfield, Hector | - |
dc.contributor.author | Paz González, Jose | - |
dc.contributor.author | Martínez Miró, Cristina | - |
dc.contributor.author | Valdés Aymerich, Lorena | - |
dc.contributor.author | Suárez, Ester | - |
dc.contributor.author | Jesús, Silvia | - |
dc.contributor.author | Aguilar, Miquel | - |
dc.contributor.author | Pastor, Pau | - |
dc.contributor.author | Planellas, Lluís | - |
dc.contributor.author | Cosgaya, Marina | - |
dc.contributor.author | García Caldentey, Juan | - |
dc.contributor.author | Caballol, Núria | - |
dc.contributor.author | Legarda, Ines | - |
dc.contributor.author | Hernández-Vara, Jorge | - |
dc.contributor.author | Cabo, Iria | - |
dc.contributor.author | López Manzanares, Lydia | - |
dc.contributor.author | González Aramburu, Isabel | - |
dc.contributor.author | Ávila Rivera, Maria Asunción | - |
dc.contributor.author | Catalán, Maria | - |
dc.contributor.author | Nogueira, Victor | - |
dc.contributor.author | Puente, Victor | - |
dc.contributor.author | Dotor, Julio | - |
dc.contributor.author | Borrué, Carmen | - |
dc.contributor.author | Solano, Berta | - |
dc.contributor.author | Álvarez Sauco, Maria | - |
dc.contributor.author | Vela, Lydia | - |
dc.contributor.author | Escalante, Sonia | - |
dc.contributor.author | Cubo, Esther | - |
dc.contributor.author | Carrillo, Francisco | - |
dc.contributor.author | Martínez Castrillo, Juan | - |
dc.contributor.author | Sánchez Alonso, Pilar | - |
dc.contributor.author | Alonso, Gemma | - |
dc.contributor.author | López Ariztegui, Nuria | - |
dc.contributor.author | Gastón, Itziar | - |
dc.contributor.author | Kulisevsky, Jaime | - |
dc.contributor.author | Blázquez, Marta | - |
dc.contributor.author | Seijo Martínez, Manuel | - |
dc.contributor.author | Rúiz Martínez, Javier | - |
dc.contributor.author | Valero, Caridad | - |
dc.contributor.author | Kurtis, Monica | - |
dc.contributor.author | Fábregues, Oriol de | - |
dc.contributor.author | Ardura, Jessica | - |
dc.contributor.author | Alonso, Ruben | - |
dc.contributor.author | Ordás, Carlos | - |
dc.contributor.author | López Díaz, Luis | - |
dc.contributor.author | Mcafee, Darrian | - |
dc.contributor.author | Martinez-Martin, Pablo | - |
dc.contributor.author | Mir, Pablo | - |
dc.contributor.author | Coppadis Study Group | - |
dc.date.accessioned | 2021-09-03T06:40:14Z | - |
dc.date.available | 2021-09-03T06:40:14Z | - |
dc.date.issued | 2021-06-30 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179843 | - |
dc.description.abstract | Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = -0.52), change from V0 to V2 in PDSS (Parkinson's Disease Sleep Scale) (β = -0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression. | - |
dc.format.extent | 25 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jpm11070626 | - |
dc.relation.ispartof | Journal of Personalized Medicine, 2021, vol. 11, issue. 7, p. 626-651 | - |
dc.relation.uri | https://doi.org/10.3390/jpm11070626 | - |
dc.rights | cc by (c) Santos García, D. et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.other | Parkinson's disease | - |
dc.title | Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-08-05T10:30:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34209166 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jpm-11-00626-v2.pdf | 1.15 MB | Adobe PDF | View/Open |
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