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http://hdl.handle.net/2445/179918
Title: | Melanogenesis and Melasma Treatment |
Author: | Solange Maddaleno, Adriana Camargo, Judit Mitjans Arnal, Montserrat Vinardell Martínez-Hidalgo, Ma. Pilar |
Keywords: | Melanina Malalties de la pell Medicaments dermatològics Melanins Skin diseases Dermatologic agents |
Issue Date: | 2-Sep-2021 |
Publisher: | MDPI |
Abstract: | Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals. The regulation of melanogenesis includes various mechanisms and factors including genetic, environmental, and endocrine factors. Knowledge of the pigmentation process is important not only to understand hyperpigmentation but also to design treatments and therapies to treat them. Whitening cosmetics with anti-melanogenesis activity are very popular. In the present manuscript, we review the mechanisms and the signalling pathways involved in skin pigmentation and we specifically focus on the alteration of melanogenesis that leads to melasma and results in hyperpigmentation. Finally, current therapies and treatments including topical, oral, and phototherapies are discussed and described, with a special emphasis on the cosmetics' action. |
Note: | Reproducció del document publicat a: https://www.mdpi.com/2079-9284/8/3/82 |
It is part of: | Cosmetics, 2021, vol. 8, num. 3, p. 82-93 |
URI: | http://hdl.handle.net/2445/179918 |
ISSN: | 2079-9284 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
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