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DC Field | Value | Language |
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dc.contributor.advisor | Nicolás Galindo, Ernesto | - |
dc.contributor.author | Riba Solé, Júlia | - |
dc.date.accessioned | 2021-09-10T13:02:34Z | - |
dc.date.available | 2022-09-07T05:10:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179975 | - |
dc.description | Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2021, Tutor: Ernesto Nicolás Galindo | ca |
dc.description.abstract | Currently, research on controlled selective release of drugs for the treatment of diseases such as cancer is a point of interest. In this sense, thermolabile ligands are a nice choice for binding the drug to a carrier in order to release it when desired by using a suitable source of heat. The Nanoscience and Bioinorganic Chemistry group (nanoBIC) of the Department of Inorganic and Organic Chemistry is investigating a system made of magnetic nanoparticles containing a 2-aminopyridine derivative as a thermolabile ligand for controlled drug release by means of an external magnetic field. The present Degree Final Work has been carried out in the framework of a collaboration between the Synthetic Methodology Applied to Bioactive Compounds group (SMBioCom) of the same department and the research group above mentioned. In this project, the 2-aminopyridine derivative of methyl 4-[N-(2-hydroxyethyl)-N-(pyridin-2-yl)aminomethyl] benzoate has been studied as precursor of potentially thermolabile carbamates or carbonates. Thus, this derivative has been synthesized and used to prepare some carbamate/carbonate derivatives. The thermal decomposition of these derivatives by intramolecular cyclization with the concomitant release of the corresponding alcohol(carbonate) or amine (carbamate) has been studied by 1H-NMR | ca |
dc.format.extent | 58 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.rights | cc-by-nc-nd (c) Riba, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Treballs Finals de Grau (TFG) - Química | - |
dc.subject.classification | Carbonats termolàbils | cat |
dc.subject.classification | Carbamats termolàbils | cat |
dc.subject.classification | Treballs de fi de grau | cat |
dc.subject.other | Thermolabile carbonates | eng |
dc.subject.other | Thermolabile carbamates | eng |
dc.subject.other | Bachelor's theses | - |
dc.title | A study on the thermal stability of carbamate and carbonate derivatives of N-(pyridin-2-yl)-2-aminoethanol | eng |
dc.title.alternative | Estudi de l’estabilitat tèrmica de derivats carbamats i carbonats de N-(piridin-2-il)-2-amionetanol | ca |
dc.type | info:eu-repo/semantics/bachelorThesis | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Treballs Finals de Grau (TFG) - Química |
Files in This Item:
File | Description | Size | Format | |
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TFG_QU Riba Solé, Júlia.pdf | 2.34 MB | Adobe PDF | View/Open |
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