Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/179994
Title: Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis
Author: Diaz Sanchis, Mireia
García Martínez, Montserrat
Vidal Lancis, Maria Carmen
Santiago, Albert
Gnutti, Gerard
Gómez Guillén, David
Trapero Bertran, Marta
Fu Balboa, Marcela
Keywords: Càncer de pulmó
Medicina preventiva
Anàlisi cost-benefici
Lung cancer
Preventive medicine
Cost effectiveness
Issue Date: 1-Sep-2021
Publisher: Elsevier BV
Abstract: Objectives: Robust economic evaluations are needed to identify efficient strategies for lung cancer prevention that combine brief and intensive smoking cessation intervention programmes with screening using low-dose computed tomography (LDCT) at different ages, frequencies, and coverages. We aimed to assess the cost-effectiveness of smoking cessation approaches combined with lung cancer screening in the European context at a population level from a societal perspective. Materials and methods: A microsimulation model that describes the natural history of lung cancer and incorporates several prevention strategies was developed. Discounted lifetime QALYs and costs at a rate of 3% were used to calculate incremental cost-effectiveness ratios, defined as additional costs in 2017 Euros per QALY gained. Results: Smoking cessation interventions reduce the incidence of lung cancer by 8%-46% and are consistently more effective and cost-effective when starting at younger ages. Screening reduces lung cancer mortality by 1%-24% and is generally less effective and more costly than smoking cessation interventions. The most cost-effective strategy would be to implement intensive smoking cessation interventions at ages 35, 40 and 45, combined with screening every three years between the ages of 55 and 65. Conclusions: Combining smoking cessation interventions with LDCT screening is a very attractive prevention strategy that substantially diminishes the burden of lung cancer. These combined prevention strategies, especially when providing several intensive interventions for smoking cessation at early ages, are more cost-effective than both approaches separately and allow for a more intensified LDCT without losing efficiency.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.lungcan.2021.06.027
It is part of: Lung Cancer, 2021, vol. 159, p. 153-161
URI: http://hdl.handle.net/2445/179994
Related resource: https://doi.org/10.1016/j.lungcan.2021.06.027
ISSN: 0169-5002
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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