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Title: | Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis |
Author: | Prieto Peña, Diana Remuzgo Martínez, Sara Genre, Fernanda Pulito Cueto, Verónica Atienza Mateo, Belén Llorca Ballester, Jaime Sevilla Pérez, Belén Ortego Centeno, Norberto Marquez, Ana Lera Gómez, Leticia Leonardo, María Teresa Peñalba, Ana Narváez García, Francisco Javier Martín Penagos, Luis Rodrigo, Emilio Miranda Filloy, José A. Caminal Montero, Luis Collado, Paz Sánchez Pérez, Javier Argila, Diego de Rubio, Esteban León Luque, Manuel Blanco Madrigal, Juan María Galíndez Agirregoikoa, Eva Gualillo, Oreste Martín, Javier Castañeda, Santos Blanco, Ricardo González Gay, Miguel A. López Mejías, Raquel |
Keywords: | Malalties vasculars Genètica mèdica Vascular diseases Medical genetics |
Issue Date: | 9-Aug-2021 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-95762-5 |
It is part of: | Scientific Reports, 2021, vol. 11 |
URI: | http://hdl.handle.net/2445/179997 |
Related resource: | https://doi.org/10.1038/s41598-021-95762-5 |
ISSN: | 2045-2322 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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