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Title: Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis
Author: Serra Blasco, María
Radua, Joaquim
Soriano Mas, Carles
Gómez Benlloch, Alba
Porta Casteràs, Daniel
Carulla, Montserrat, 1930-
Albajes Eizagirre, Anton
Arnone, Danilo
Klauser, Paul
Canales Rodríguez, Erick Jorge
Hilbert, Kevin
Wise, Toby
Cheng, Yuqui
Kandilarova, Sevdalina
Mataix Cols, David
Vieta i Pascual, Eduard, 1963-
Via, Esther
Cardoner, N. (Narcís)
Keywords: Psicopatologia
Psychology, Pathological
Issue Date: 11-Jul-2021
Publisher: Elsevier
Abstract: The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.
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It is part of: Neuroscience & Biobehavioral Reviews, 2021, vol. 129, p. 269-281
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ISSN: 0149-7634
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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