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DC Field | Value | Language |
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dc.contributor.author | Rovira, Meritxell | - |
dc.contributor.author | Atla, Goutham | - |
dc.contributor.author | Maestro, Miguel Angel | - |
dc.contributor.author | Grau, Vanessa | - |
dc.contributor.author | García Hurtado, Javier | - |
dc.contributor.author | Ferrer, Jorge | - |
dc.contributor.author | Maqueda, Maria | - |
dc.contributor.author | Mosquera Mayo, José Luís | - |
dc.contributor.author | Kerr-Conte, Julie | - |
dc.contributor.author | Pattou, Francois | - |
dc.date.accessioned | 2021-09-21T11:02:58Z | - |
dc.date.available | 2021-09-21T11:02:58Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180146 | - |
dc.description.abstract | Understanding genomic regulatory mechanisms of pancreas differentiation is relevant to the pathophysiology of diabetes mellitus, and to the development of replacement therapies. Numerous transcription factors promote β cell differentiation, although less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrine gene programs in the embryonic pancreas. However, pancreatic Rest knock-out mice failed to show increased numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we now observe a marked increase in the formation of pancreatic endocrine cells. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts, and induced β-cell specific genes in human adult ductderived organoids. Finally, we define REST genomic programs that suppress pancreatic endocrine differentiation. These results establish a crucial role of REST as a negative regulator of pancreatic endocrine differentiation. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1101/gad.348501.121 | - |
dc.relation.ispartof | Genes & Development, 2021, vol. 35, num. 17-18, p. 1229-1243 | - |
dc.relation.uri | https://doi.org/10.1101/gad.348501.121 | - |
dc.rights | cc by (c) Rovira, Meritxell et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Pàncrees | - |
dc.subject.classification | Organogènesi | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.other | Pancreas | - |
dc.subject.other | Organogenesis | - |
dc.subject.other | Molecular biology | - |
dc.title | REST is a major negative regulator of endocrine differentiation during pancreas organogenesis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 713535 | - |
dc.date.updated | 2021-09-21T11:02:58Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/789055/EU//DecodeDiabetes | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34385258 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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713535.pdf | 7.71 MB | Adobe PDF | View/Open |
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