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Title: | Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life. |
Author: | Santos García, Diego De Deus Fonticoba, Teresa Paz González, Jose Cores Bartolomé, Carlos Valdés Aymerich, Lorena Muñoz Enríquez, J. G. Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, María José Nogueira, Victor Puente, Victor García Moreno, Jose Manuel Borrué, Carmen Solano Vila, Berta Álvarez Sauco, Maria Vela, Lydia Escalante Arroyo, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso Losada, Maria Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez Estrada, M. Seijo Martínez, Manuel Rúiz Martínez, Javier |
Keywords: | Malaltia de Parkinson Parkinson's disease |
Issue Date: | 15-May-2021 |
Publisher: | Hindawi |
Abstract: | Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2021/8871549 |
It is part of: | Parkinson's Disease, 2021 |
URI: | http://hdl.handle.net/2445/180192 |
Related resource: | https://doi.org/10.1155/2021/8871549 |
ISSN: | 2042-0080 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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