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http://hdl.handle.net/2445/180276
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DC Field | Value | Language |
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dc.contributor.author | Bastidas Mora, Gabriela | - |
dc.contributor.author | Beà Bobet, Sílvia M. | - |
dc.contributor.author | Navarro, Alba | - |
dc.contributor.author | Gine, Eva | - |
dc.contributor.author | Costa, Dolors | - |
dc.contributor.author | Delgado, Julio (Delgado González) | - |
dc.contributor.author | Baumann, Tycho | - |
dc.contributor.author | Magnano, Laura | - |
dc.contributor.author | Rivas Delgado, Alfredo | - |
dc.contributor.author | Villamor i Casas, Neus | - |
dc.contributor.author | Colomer Pujol, Dolors | - |
dc.contributor.author | López Guerra, Mònica | - |
dc.contributor.author | Rozman, María | - |
dc.contributor.author | Balagué, Olga | - |
dc.contributor.author | Martínez Hernández, Daniel | - |
dc.contributor.author | Baptista, Maria Joao | - |
dc.contributor.author | Escoda, Lourdes | - |
dc.contributor.author | Alcoceba, Miguel | - |
dc.contributor.author | Blanes, Margarita | - |
dc.contributor.author | Climent, Fina | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.contributor.author | Wotherspoon, Andrew | - |
dc.contributor.author | López Guillermo, Armando | - |
dc.contributor.author | Matutes, Estella | - |
dc.date.accessioned | 2021-09-27T13:04:38Z | - |
dc.date.available | 2021-09-27T13:04:38Z | - |
dc.date.issued | 2021-09-14 | - |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180276 | - |
dc.description.abstract | We describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL-T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL-T in other centres. In the HCB cohort, the cumulative incidence of transformation at 5 years was 15%. Predictors for transformation were cytopenias, hypoalbuminaemia, complex karyotype (CK) and both the Intergruppo Italiano Linfomi (ILL) and simplified Haemoglobin, Platelet count, lactate dehydrogenase (LDH) and extrahilar Lymphadenopathy (HPLL)/ABC scores (P < 0·05). The only independent predictor for transformation in multivariate analysis was CK [hazard ratio (HR) 4·025, P = 0·05]. Patients with SMZL-T had a significantly higher risk of death than the remainder (HR 3·89, P < 0·001). Of the 36 patients with SMZL-T, one developed Hodgkin lymphoma and 35 a diffuse large B-cell lymphoma, 71% with a non-germinal centre phenotype. The main features were B symptoms, lymphadenopathy, and high serum LDH. CK was observed in 12/22 (55%) SMZL-T and fluorescence in situ hybridisation detected abnormalities of MYC proto-oncogene, basic helix-loop-helix transcription factor (MYC), B-cell leukaemia/lymphoma 2 (BCL2) and/or BCL6 in six of 14 (43%). In all, 21 patients received immunochemotherapy, six chemotherapy, one radiotherapy and three splenectomy. The complete response (CR) rate was 61% and the median survival from transformation was 4·92 years. Predictors for a worse survival in multivariate analysis were high-risk International Prognostic Index (HR 5·294, P = 0·016) and lack of CR (HR 2·67, P < 0·001). | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1111/bjh.17815 | - |
dc.relation.ispartof | British Journal of Haematology, 2021, vol. 194 | - |
dc.relation.uri | https://doi.org/10.1111/bjh.17815 | - |
dc.rights | cc by-nc (c) Bastidas Mora, Gabriela et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.classification | Càncer | - |
dc.subject.other | B cells | - |
dc.subject.other | Cancer | - |
dc.title | Clinico‐biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-09-23T09:04:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34519021 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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