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Title: Integrating magnetic capabilities to intracellular chips for cell trapping
Author: Arjona, María isabel
González-Manchón, Consuelo
Durán, Sara
Duch, Marta
del Real, Rafael P.
Kadambi, Abhinav
Agusil, Juan Pablo
Redondo-Horcajo, Mariano
Pérez García, M. Lluïsa (Maria Lluïsa)
Gómez, Elvira
Suárez, Teresa
Plaza, José Antonio
Keywords: Microtecnologia
Aliatges de cobalt
Cobalt alloys
Issue Date: 16-Sep-2021
Publisher: Nature Publishing Group
Abstract: Current microtechnologies have shown plenty of room inside a living cell for silicon chips. Microchips as barcodes, biochemical sensors, mechanical sensors and even electrical devices have been internalized into living cells without interfering their cell viability. However, these technologies lack from the ability to trap and preconcentrate cells in a specific region, which are prerequisites for cell separation, purification and posterior studies with enhanced sensitivity. Magnetic manipulation of microobjects, which allows a non-contacting method, has become an attractive and promising technique at small scales. Here, we show intracellular Ni-based chips with magnetic capabilities to allow cell enrichment. As a proof of concept of the potential to integrate multiple functionalities on a single device of this technique, we combine coding and magnetic manipulation capabilities in a single device. Devices were found to be internalized by HeLa cells without interfering in their viability. We demonstrated the tagging of a subpopulation of cells and their subsequent magnetic trapping with internalized barcodes subjected to a force up to 2.57 pN (for magnet-cells distance of 4.9 mm). The work opens the venue for future intracellular chips that integrate multiple functionalities with the magnetic manipulation of cells.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2021, vol. 11, p. 18495
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Ciència dels Materials i Química Física)

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