Please use this identifier to cite or link to this item:
Title: Risk of Developing Epilepsy after Autoimmune Encephalitis
Author: Gifreu, Ariadna
Falip, Mercè
Sala Padró, Jacint
Mongay, Neus
Morandeira-Rego, Francisco
Camins, Àngels
Naval Baudin, Pablo
Veciana de las Heras, Misericordia
Fernández, Montserrat
Pedro, Jordi
Garcia Parra, Belia
Arroyo, Pablo
Simó, Marta
Keywords: Encefalitis
Issue Date: 8-Sep-2021
Publisher: MDPI AG
Abstract: Background: Acute symptomatic seizures (ASS) are a common manifestation of autoimmune encephalitis (AE), but the risk of developing epilepsy as a sequela of AE remains unknown, and factors predisposing the development of epilepsy have not been fully identified. Objective: To assess the risk of developing epilepsy in AE and study related risk factors. Materials and methods: This was a retrospective single centre study including patients diagnosed with AE according to criteria described by Graus et al., with a minimum follow-up of 12 months after AE resolution. The sample was divided according to whether patients developed epilepsy or not. Results: A total of 19 patients were included; 3 (15.8%) had AE with intracellular antibodies, 9 (47.4%) with extracellular antibodies, and 7 (36.8%) were seronegative. During follow-up, 3 patients (15.8%) died, 4 (21.1%) presented relapses of AE, and 11 (57.89%) developed epilepsy. There was a significant association between the development of epilepsy and the presence of hippocampal atrophy in control brain magnetic resonance imaging (MRI) (p = 0.037), interictal epileptiform discharges (IED) on control electroencephalogram (EEG) (p = 0.045), and immunotherapy delay (p = 0.016). Conclusions: Hippocampal atrophy in neuroimaging, IED on EEG during follow-up, and immunotherapy delay could be predictors of the development of epilepsy in patients with AE.
Note: Reproducció del document publicat a:
It is part of: Brain Sciences, 2021, vol. 11, num. 9, p. 1182
Related resource:
ISSN: 2076-3425
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
brainsci-11-01182.pdf5.75 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons