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Title: An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
Author: Peña Arteaga, Víctor de la
Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina
Abulafia, Carolina
Cardoner, N. (Narcís)
Castro, Mariana N.
Villarreal, Mirta
Menchón Magriñá, José Manuel
Guinjoan, Salvador M.
Soriano Mas, Carles
Keywords: Diagnòstic per la imatge
Depressió psíquica
Trastorns de la personalitat
Diagnostic imaging
Depression, Mental
Personality disorders
Issue Date: 2021
Publisher: Cambridge University Press
Citation: De la Peña-Arteaga V, Berruga-Sánchez M, Steward T, Martínez-Zalacaín I, Goldberg X, Wainsztein A, Abulafia C, Cardoner N, Castro MN, Villarreal M, Menchón JM, Guinjoan SM, Soriano-Mas C. An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder. Eur Psychiatry. 2021 Sep 1;64(1):e56. doi: 10.1192/j.eurpsy.2021.2231. PMID: 34465401.
Abstract: Background: One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations. Methods: We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity. Results: When compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions: This study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders.
Note: Reproducció del document publicat a: https;//
It is part of: European Psychiatry, 2021, vol 64, num. 1
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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