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http://hdl.handle.net/2445/180372
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DC Field | Value | Language |
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dc.contributor.author | Genescà, Eulàlia | - |
dc.contributor.author | Morgades, Mireia | - |
dc.contributor.author | González Gil, Celia | - |
dc.contributor.author | Fuster Tormo, Francisco | - |
dc.contributor.author | Haferlach, Claudia | - |
dc.contributor.author | Meggendorfer, Manja | - |
dc.contributor.author | Montesinos, Pau | - |
dc.contributor.author | Barba, Pere | - |
dc.contributor.author | Gil, Cristina | - |
dc.contributor.author | Coll, Rosa | - |
dc.contributor.author | Moreno, María José | - |
dc.contributor.author | Martínez Carballeira, Daniel | - |
dc.contributor.author | García Cadenas, Irene | - |
dc.contributor.author | Vives, Susana | - |
dc.contributor.author | Ribera, Jordi | - |
dc.contributor.author | González Campos, José | - |
dc.contributor.author | Díaz Beyà, Marina | - |
dc.contributor.author | Mercadal, Santiago | - |
dc.contributor.author | Artola, María Teresa | - |
dc.contributor.author | Cladera, Antonia | - |
dc.contributor.author | Tormo, Mar | - |
dc.contributor.author | Bermúdez, Arancha | - |
dc.contributor.author | Vall Llovera, Ferran | - |
dc.contributor.author | Martínez Sánchez, Pilar | - |
dc.contributor.author | Amigo, María Luz | - |
dc.contributor.author | Monsalvo, Silvia | - |
dc.contributor.author | Novo, Andrés | - |
dc.contributor.author | Cervera, Marta | - |
dc.contributor.author | García Guiñon, Antonio | - |
dc.contributor.author | Ciudad, Juana | - |
dc.contributor.author | Cervera, José | - |
dc.contributor.author | Hernández Rivas, Jesús María | - |
dc.contributor.author | Granada, Isabel | - |
dc.contributor.author | Haferlach, Torsten | - |
dc.contributor.author | Orfao, Alberto | - |
dc.contributor.author | Solé, Francesc | - |
dc.contributor.author | Ribera, Josep Maria | - |
dc.date.accessioned | 2021-10-04T07:32:18Z | - |
dc.date.available | 2021-10-04T07:32:18Z | - |
dc.date.issued | 2021-10-01 | - |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180372 | - |
dc.description.abstract | The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of ≥3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with ≥3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with ≥3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying ≥3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.leukres.2021.106612 | - |
dc.relation.ispartof | Leukemia Research, 2021, vol. 109, p. 106612 | - |
dc.relation.uri | https://doi.org/10.1016/j.leukres.2021.106612 | - |
dc.rights | cc by-nc-nd (c) Genescà, Eulàlia et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Citogenètica humana | - |
dc.subject.classification | Leucèmia | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Human cytogenetics | - |
dc.subject.other | Leukemia | - |
dc.subject.other | Prognosis | - |
dc.title | Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-10-01T11:41:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34139642 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0145212621001132-main.pdf | 1.36 MB | Adobe PDF | View/Open |
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