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Title: | Prognostic heterogeneity of adult B‐cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/ TCF3‐PBX1 treated with measurable residual disease‐oriented protocols |
Author: | Ribera, Jordi Granada, Isabel Morgades, Mireia González, Teresa Ciudad, Juana Such, Esperanza Calasanz, María José Mercadal, Santiago Coll, Rosa González Campos, José Tormo, Mar García Cadenas, Irene Gil, Cristina Cervera, Marta Barba, Pere Costa, Dolors Ayala, Rosa Bermúdez, Arancha Orfao, Alberto Ribera, Josep Maria Programa Español de Tratamiento en Hematología (PETHEMA) Group Spanish Society Of Hematology (SEHH) |
Keywords: | Pronòstic mèdic Leucèmia Citogenètica humana Prognosis Leukemia Human cytogenetics |
Issue Date: | 21-Sep-2021 |
Publisher: | Wiley |
Abstract: | The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the outcome of adolescent and adult patients with t(1;19)(q23;p13) enrolled in paediatric-inspired trials. The patients with TCF3-PBX1 showed similar MRD clearance and did not have different survival compared with other B-cell precursor ALL patients. However, patients with TCF3-PBX1 had a significantly higher cumulative incidence of relapse, especially among patients aged ≥35 years carrying additional cytogenetic alterations. These patients might benefit from additional/intensified therapy (e.g. immunotherapy in first complete remission with or without subsequent haematopoietic stem cell transplantation). |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/bjh.17844 |
It is part of: | British Journal of Haematology, 2021, vol. 194 |
URI: | http://hdl.handle.net/2445/180373 |
Related resource: | https://doi.org/10.1111/bjh.17844 |
ISSN: | 1365-2141 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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