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http://hdl.handle.net/2445/180394
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DC Field | Value | Language |
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dc.contributor.advisor | Proteïnúria | - |
dc.contributor.author | Rodríguez Rodríguez, Rosa | - |
dc.contributor.author | Hojs, Radovan | - |
dc.contributor.author | Trevisani, Francesco | - |
dc.contributor.author | Morales, Enrique | - |
dc.contributor.author | Fernández, Gema | - |
dc.contributor.author | Bevc, Sebastjan | - |
dc.contributor.author | Cases Corona, Clara Maria | - |
dc.contributor.author | Cruzado, Josep Ma. | - |
dc.contributor.author | Quero Ramos, Maria | - |
dc.contributor.author | Navarro Díaz, Maruja | - |
dc.contributor.author | Bettiga, Arianna | - |
dc.contributor.author | Di Marco, Federico | - |
dc.contributor.author | López Martínez, Marina | - |
dc.contributor.author | Moreso, Francesc | - |
dc.contributor.author | García Garro, Clara | - |
dc.contributor.author | Khazim, Khaled | - |
dc.contributor.author | Ghanem, Fedaa | - |
dc.contributor.author | Praga, Manuel | - |
dc.contributor.author | Ibernón, Meritxell | - |
dc.contributor.author | Laranjinha, Ivo | - |
dc.contributor.author | Mendonça, Luís | - |
dc.contributor.author | Bigotte Vieira, Miguel | - |
dc.contributor.author | Hornum, Mads | - |
dc.contributor.author | Feldt-Rasmussen, Bo | - |
dc.contributor.author | Fernández Fernández, Beatriz | - |
dc.contributor.author | Fox, Patricia Concepción | - |
dc.contributor.author | Negrín Mena, Natalia | - |
dc.contributor.author | Ortiz, Alberto | - |
dc.contributor.author | Porrini, Esteban | - |
dc.date.accessioned | 2021-10-04T09:43:07Z | - |
dc.date.available | 2021-10-04T09:43:07Z | - |
dc.date.issued | 2021-09-01 | - |
dc.identifier.issn | 2468-0249 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180394 | - |
dc.description.abstract | Introduction: The clinical-histologic correlation in diabetic nephropathy is not completely known. Methods: We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular filtration rate (GFR). Results: Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, and 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% <60 ml/min per 1.73 m2). About 170 glomeruli per patient were analyzed, and all samples included vascular tissue. Six subjects (7%) were classified in diabetic nephropathy class I, 61 (68%) in class II-a, 13 (14%) in class II-b, 9 (10%) class III, and 1 (1%) in class IV. Eighty percent to 90% of those with normoalbuminuria or microalbuminuria were classified in class II-a or II-b and <10% in class III; 52% of those with proteinuria were in class II-a, 15% in class II-b, and 19% in class III. Nodular sclerosis (57%) and mesangial expansion (15%) were more frequent in cases with proteinuria than in normoalbuminuria (28% and 8%; P = 0.028 and 0.017). About 20% to 30% of all cases, regardless the level of albuminuria or proteinuria or the histologic class had tubular atrophy, interstitial fibrosis, or inflammation in >10% to 20% of the sample. Moderate hyalinosis and arteriolar sclerosis were observed in 80% to 100% of cases with normoalbuminuria, microalbuminuria, proteinuria, as well as in class I, II, or III. Conclusions: Weak correspondence between analytical parameters and kidney histology was found. Thus, disease may progress undetected from the early clinical stages of the disease. Finally, vascular damage was a very common finding, which highlights the role of ischemic intrarenal disease in diabetes. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ekir.2021.06.001 | - |
dc.relation.ispartof | Kidney International Reports, 2021, vol. 6, num. 9, p. 2392-2403 | - |
dc.relation.uri | https://doi.org/10.1016/j.ekir.2021.06.001 | - |
dc.rights | cc by-nc-nd (c) Rodríguez Rodríguez, Rosa et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Nefropaties diabètiques | - |
dc.subject.other | Diabetic nephropathies | - |
dc.subject.other | Proteinuria | - |
dc.title | The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-10-01T08:20:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34514200 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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PIIS2468024921012274.pdf | 1.59 MB | Adobe PDF | View/Open |
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