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Title: Effects of a postbiotic and prebiotic mixture on suckling rats' microbiota and immunity
Author: Morales Ferré, Carla
Azagra Boronat, Ignasi
Massot Cladera, Malen
Tims, S.
Knipping, K.
Garssen, J.
Knol, J.
Franch i Masferrer, Àngels
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Keywords: Prebiòtics
Rates (Animals de laboratori)
Cries d'animals
Rats as laboratory animals
Young animals
Issue Date: 27-Aug-2021
Publisher: MDPI
Abstract: Human milk serves as a model for infant formula providing nutritional solutions for infants not able to receive enough mother's milk. Infant formulas aim to mimic the composition and functionality of human milk by providing ingredients reflecting those of the latest human milk insights, such as prebiotics, probiotics and postbiotics. The aim of this study was to examine the effects of the supplementation with a postbiotic (LactofidusTM) and its combination with the prebiotics short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) in a preclinical model of healthy suckling rats. Pups were supplemented daily with LactofidusTM (POST group) and/or scGOS/lcFOS (P+P and PRE groups, respectively). Body weight and fecal consistency were analyzed. At the end of the study, immunoglobulin (Ig) profile, intestinal gene expression, microbiota composition and short chain fatty acid (SCFA) proportion were quantified. The supplementation with all nutritional interventions modulated the Ig profile, but the prebiotic mixture and the postbiotic induced differential effects: whereas scGOS/lcFOS induced softer feces and modulated microbiota composition and SCFA profile, Lactofidus upregulated Toll-like receptors gene expression. The use of the combination of scGOS/lcFOS and Lactofidus showed the effects observed for the oligosaccharides separately, as well as showing a synergistic impact on animal growth. Thus, the combined use of both products seems to be a good strategy to modulate immune and microbial features in early life. View Full-Text Keywords: postbiotic; prebiotic; suckling rats; Lactofidus; scGOS/lcFOS; microbiota; SCFA
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2021, vol. 13, num. 9, p. 2975
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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