Title: | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
Author: | Torres Martí, Antoni Motos, Ana Riera, Jordi Fernández Barat, Laia Ceccato, Adrian Pérez Arnal, Raquel García Gasulla, Dario Peñuelas, Oscar Lorente, José Angel Rodriguez Oviedo, Alejandro Gonzalo Calvo, David de Macias Guerrero, Desire Torre, Maria del Carmen de la Iglesias, Silvia Casacuberta Barberà, Núria Janer, Maria Teresa Jiménez, Gabriel Serra Fortuny, Mireia Vidal Cortes, Pablo Juan Díaz, Mar Rodríguez Ruiz, Covadonga Arrieta, Marta Valdivia Ruiz, Luis Novo, Mariana Andrea Saborido Paz, Eva Speziale, Carla Barberán, José Serrano Lázaro, Ainhoa Jorge García, Ruth Noemí Santacoloma, Bitor Mamolar Herrera, Nuria Martínez Juan, Maria Dolores Monclou, Josman Gallego, Elena Salvador Adell, Inmaculada Pozo Laderas, Juan Carlos Masa Jimenez, Juan Fernando Vallverdú, Montserrat Díaz Santos, Emili Masclans, Joan Ramon Moreno Cano, Sara Guadalupe Martínez de la Gándara, Amalia Moral Parras, Pedro Agrifoglio, Alexander Piñol-tena, Àngels García, Beatriz Maseda, Emilio Menor Fernández, Eva María Vilanova, Judit Huerta, Arturo Miralbés, Mar Estella, Ángel Parera Pous, Anna Climent, Cristina Yang, Minlan Socias, Lorenzo Villada Warrington, Tatiana Álvarez, Sergio Carbajales Pérez, Cristina Morales, Dulce Barberà, Carme Mariño, Ana Balan Almansa Mora, Raquel Ortega, Ana Conde, Pamela Aguilar Cabello, María Pujol, Andrés Rubio, Jorge Ángel, José Cicuendez Ávila, Ramon Soliva, Laura Ramon Coll, Núria Renedo Sanchez-Giron, Gloria Loza Vázquez, Ana Alegre, Cynthia Roche Campo, Ferran Aguilera, Luciano Sariñena, Maria Teresa Gomà, Gemma Barbeta, Enric Marin Corral, Judith Suares Sipmann, Fernando Blandino Ortiz, Aaron Sancho Chinesta, Susana Cantón-bulnes, Maria Luisa Albaiceta, Guillermo M. Sánchez, Ana Gómez, Silvia Tognetti, Daniel Urrelo Cerrón, Luis Bustamante-munguira, Juan Codina, Jordi Clar, Luisa Tormos, Adrián Álvarez Ruiz, Antonjo Bofill, Neus Torres, Mateu Vengoechea, Javier Marco Naya, Gregorio Carvalho, Sula Vara Adrio, Sabela Enríquez Giraudo, Pedro Caballero, Jesús Ocón, Marta Trefler, Sandra Trujillano, Javier Balsera, Begoña Cano, Iosune Úbeda, Alejandro Alcaraz Serrano, Victoria Bouza Vieiro, María Teresa Menéndez, Rosario Andrea, Rut Barral Segade, Patricia Martin, María Cruz Barbena, Laura Forcelledo Espina, Lorena Badia, Joan Ramon Vázquez, Nil Zapatero, Ana Fernández, Javier Gómez Casal, Vanesa Gascón Castillo, Maria Luisa CIBERESUCICOVID Project (COV20/00110, ISCIII) Bueno, Leticia Esmorís Arijón, Inés Carbonell, Nieves Gómez, José M. García, Felipe García Garmendia, José Luis Solé Violán, Jordi Sanchez, Miguel Catalán González, Mercedes Galbán, Cristóbal Cardina Fernández, Pablo Forcadell Ferreres, Eva Gumucio Sanguino, Víctor D. Farre Monjo, Teresa Peñasco, Yhivian Pérez Bastida, Leire González, Jessica Carrión García, Laura León, Miguel Busto Martínez, Cecilia del Garnacho Montero, José Contreras, Sofía Marcos, Pilar Castro, Pedro López Messa, Juan Pérez Planelles, Gloria Tamayo Lomas, Luis Aldecoa, César López Lago, Ana Pagliarani, Pablo Bardi, Tommaso Trenado, José Barbé, Ferran Franco, Nieves Lazo Álvarez, Juan I. Adell Serrano, Berta Badía, Mariona Segura Pensado, Marta Martínez, María Furro, Àngels Gracia, Maria Pilar Pablo Sánchez, Raul de Gómez Gonzalez, Carmen Muñoz Bermúdez, Rosana García Redruello, Carlos Ayestaran, Ignacio Barroso, Marta Bodi Saera, María Mora Aznar, María Pérez, Purificación Parrilla, Francisco Berezo García, José Ángel López Gavín, Alexandre Montejo González, Juan Carlos Bigas, Judit Campos Fernández, Sandra Nogueras Salinas, Rafaela Cachafeiro, Lucia Rodriguez, Laura Mendoza, Diego de Martínez Varela, Ignacio Blancas, Rafael Blasco Cortés, María Luisa Marmol Peis, Enrique Mosquera Rodríguez, David Boado, María Montserrat, Neus Cillóniz, Catia Ferrer Roca, Ricard Martínez Fernández, Carmen Eulalia Pestaña Laguna, David Martín Vicente, Paula Ruiz Miralles, Miriam Mañez Mendiluce, Rafael Campi Hermoso, David Castellà, Manuel Serra, Lidia Bustamante Munguira, Elena Castellví, Andrea Añón, José M. Rodríguez de Castro, Felipe Díaz, Yolanda Figueras, Albert Salazar Degracia, Ana Gabarrús, Albert Gordo, Federico Rivas Vilas, María Digna Dólera Moreno, Cristina Nicolás Arfelis, Josep Maria Rubio López, Alberto Dot, Irene Rodríguez, Silvia García Sagastume, Amaia Ricart, Pilar Servià, Lluís Nogue Bou, Ramon Prados, Javier Ferrando, Carlos Pérez Rubio, Eva Vilà Vilardel, Clara Ossa, Sergio García Prieto, Emilio Sánchez Miralles, Angel Herraiz, Alba Kiarostami, Karsa Van Der Hofstadt Martin-Montalvo, Maria Amaya Villar, Rosario Bermejo Martín, Jesús F. Herrán Monge, Rubén Ryan Murúa, Pablo Val, Estela Ibarz, Mercedes Mantellini, Cecilia L. Báez Pravia, Orville Yang, Hua |
Keywords: | COVID-19 Respiració artificial Pronòstic mèdic COVID-19 Artificial respiration Prognosis |
Issue Date: | 13-Sep-2021 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation. |
Note: | Following publication of the original article at https://doi.org/10.1186/s13054-021-03727-x the authors identified an error in the Funding section that has been corrected (https://doi.org/10.1186/s13054-021-03849-2) |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03727-x |
It is part of: | Critical Care, 2021, vol. 25, num. 1 |
URI: | http://hdl.handle.net/2445/180518 |
Related resource: | https://doi.org/10.1186/s13054-021-03727-x https://doi.org/10.1186/s13054-021-03849-2 |
ISSN: | 1364-8535 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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