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Title: | Modelling the optimal sequence of biologic therapies in plaque psoriasis in Spain |
Author: | Egeberg, Alexander Danø, Anne Pedersen, Mikkel H. Sohrt, Anne Borg, Emma Notario, Jaime |
Keywords: | Psoriasi Immunosupressors Anàlisi cost-benefici Psoriasis Immunosupressive agents Cost effectiveness |
Issue Date: | 20-Aug-2021 |
Publisher: | Informa UK Limited |
Abstract: | Aim: The purpose of this manuscript was to illustrate the impact of the place in the treatment sequence on the cost and cost-effectiveness of different biologics for patients with moderate-to-severe plaque psoriasis. Materials and methods: We developed a treatment sequence model and focused on seven different biological treatment options and 840 combinations of treatment sequences. The model converted cost of treatment to a cost per responder by dividing treatment cost by expected number of patients achieving PASI100 after 52 weeks of treatment. We used Spanish ex-factory price levels, dosing recommendations and real-world data on drug survival to calculate the treatment costs. Results: The most cost-effective treatment sequence was brodalumab-risankizumab-guselkumab-ixekizumab, with a cost per responder of €139,281 during the first five years of treatment. In comparison, if brodalumab was not recommended as first-line therapy, total costs would increase by 7.4% to €149,616. If brodalumab was not recommended as any of the first four lines of treatment, total costs would increase by 13.1% to €157,527 relative to the most cost-effective treatment sequence. Conclusions: A sequential therapy model may improve efficiency in the treatment of psoriasis. According to our results, brodalumab as the first-line therapy in Spain leads to the most cost-effective treatment sequence. |
Note: | Reproducció del document publicat a: https://doi.org/10.1080/13696998.2021.1970953 |
It is part of: | Journal of Medical Economics, 2021, vol. 24, num. 1, p. 1134-1142 |
URI: | http://hdl.handle.net/2445/180634 |
Related resource: | https://doi.org/10.1080/13696998.2021.1970953 |
ISSN: | 1941-837X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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