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http://hdl.handle.net/2445/180635
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DC Field | Value | Language |
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dc.contributor.author | Canaslan, Sezgi | - |
dc.contributor.author | Schmitz, Matthias | - |
dc.contributor.author | Villar Piqué, Anna | - |
dc.contributor.author | Maass, Fabian | - |
dc.contributor.author | Gmitterová, Karin | - |
dc.contributor.author | Varges, Daniela | - |
dc.contributor.author | Lingor, Paul | - |
dc.contributor.author | Llorens Torres, Franc | - |
dc.contributor.author | Hermann, Peter | - |
dc.contributor.author | Zerr, Inga | - |
dc.date.accessioned | 2021-10-18T07:25:10Z | - |
dc.date.available | 2021-10-18T07:25:10Z | - |
dc.date.issued | 2021-09-22 | - |
dc.identifier.uri | http://hdl.handle.net/2445/180635 | - |
dc.description.abstract | Alpha-synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are a class of neurodegenerative diseases. A diagnosis may be challenging because clinical symptoms partially overlap, and there is currently no reliable diagnostic test available. Therefore, we aimed to identify a suitable marker protein in cerebrospinal fluid (CSF) to distinguish either between different types of alpha-synucleinopathies or between alpha-synucleinopathies and controls. In this study, the regulation of different marker protein candidates, such as alpha-synuclein (a-Syn), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total tau (tau) in different types of alpha-synucleinopathies, had been analyzed by using an ultrasensitive test system called single-molecule array (SIMOA). Interestingly, we observed that CSF-NfL was significantly elevated in patients with DLB and MSA compared to patients with PD or control donors. To differentiate between groups, receiver operating characteristic (ROC) curve analysis resulted in a very good diagnostic accuracy as indicated by the area under the curve (AUC) values of 0.87-0.92 for CSF-NfL. Furthermore, we observed that GFAP and tau were slightly increased either in DLB or MSA, while a-Syn levels remained unregulated. Our study suggests NfL as a promising marker to discriminate between different types of alpha-synucleinopathies or between DLB/MSA and controls. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2021.717930 | - |
dc.relation.ispartof | Frontiers in Aging Neuroscience, 2021, vol. 13 num. 717930 | - |
dc.relation.uri | https://doi.org/10.3389/fnagi.2021.717930 | - |
dc.rights | cc by (c) Canaslan, Sezgi et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Líquid cefalorraquidi | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.other | Cerebrospinal fluid | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.title | Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-10-14T08:46:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34630068 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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fnagi-13-717930.pdf | 2.14 MB | Adobe PDF | View/Open |
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