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http://hdl.handle.net/2445/180671
Title: | The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells |
Author: | Núñez-Vázquez, Sonia Saura-Esteller, José Sánchez Vera, Ismael Guilbaud, Emma Cosialls Castel, Ana Mª Pons i Irazazábal, Gabriel Ricci, Jean-Ehrland Iglesias i Serret, Daniel Marchetti, Sandrine Gil i Santano, Joan |
Keywords: | Apoptosi Cèl·lules canceroses Mitocondris Càncer Apoptosis Cancer cells Mitochondria Cancer |
Issue Date: | 27-Sep-2021 |
Publisher: | Nature Publishing Group |
Abstract: | Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was described that PHB (Prohibitin) 1 and 2 are crucial mitophagy receptors involved in mediating the autophagic degradation of mitochondria. We measured mitophagy in HeLa cells expressing Parkin and in A549, a lung cancer cell line that can undergo mitophagy in a Parkin-independent manner, and we demonstrated that both fluorizoline and rocaglamide A, another PHB-binding molecule, inhibit CCCP- and OA-induced mitophagy. Moreover, we demonstrated that PHBs are mediating Parkin-dependent mitophagy. In conclusion, besides being a potent pro-apoptotic compound, we present fluorizoline as a promising new mitophagy modulator that could be used as anticancer agent. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41389-021-00352-9 |
It is part of: | Oncogenesis, 2021, vol. 10, num. 64 |
URI: | http://hdl.handle.net/2445/180671 |
Related resource: | https://doi.org/10.1038/s41389-021-00352-9 |
ISSN: | 2157-9024 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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