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http://hdl.handle.net/2445/180672
Title: | Mesoscale physical principles of collective cell organization |
Author: | Trepat Guixer, Xavier Sahai, Erik |
Keywords: | Propietats mecàniques Biomolècules Cèl·lules Citosquelet Mechanical properties Biomolecules Cells Cytoskeleton |
Issue Date: | 4-Jul-2018 |
Publisher: | Nature Publishing Group |
Abstract: | We review recent evidence showing that cell and tissue dynamics are governed by mesoscale physical principles. These principles can be understood in terms of simple state diagrams in which control variables include force, density, shape, adhesion and self-propulsion. An appropriate combination of these physical quantities gives rise to emergent phenomena such as cell jamming, topological defects and underdamped waves. Mesoscale physical properties of cell assemblies are found to precede and instruct biological functions such as cell division, extrusion, invasion and gradient sensing. These properties are related to properties of biomolecules, but cannot be predicted from biochemical principles. Thus, biological function is governed by emergent mesoscale states that can be predicted by a simple set of physical properties. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41567-018-0194-9 |
It is part of: | Nature Physics, 2018, vol. 14, p. 671-682 |
URI: | http://hdl.handle.net/2445/180672 |
Related resource: | https://doi.org/10.1038/s41567-018-0194-9 |
ISSN: | 1745-2473 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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683526.pdf | 1.26 MB | Adobe PDF | View/Open |
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