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http://hdl.handle.net/2445/180829
Title: | Functional Connectivity Analysis of Stem Cell Cultures with Parkinson’s Disease |
Author: | López Poyatos, Ana |
Director/Tutor: | Soriano i Fradera, Jordi |
Keywords: | Xarxes neuronals (Neurobiologia) Cèl·lules mare Malaltia de Parkinson Treballs de fi de grau Neural networks (Neurobiology) Stem cells Parkinson's disease Bachelor's theses |
Issue Date: | Jul-2021 |
Abstract: | We studied the activity and functional network characteristics of neurons derived from human induced pluripotent stem cells (iPSCs) grown in culture. The cells were obtained from healthy and Parkinson’s–affected patients. Using a network perspective, different magnitudes were analyzed to demonstrate connectivity and activity differences between healthy controls, diseased Parkinson’s cultures, and genetically cured ones. We unveiled an excess of integration and a loss of both modularity and small–worldness for Parkinson’s diseased cultures. The study may help the medical society to better understand the disease and develop efficient therapies |
Note: | Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2021, Tutor: Jordi Soriano Fradera |
URI: | http://hdl.handle.net/2445/180829 |
Appears in Collections: | Treballs Finals de Grau (TFG) - Física |
Files in This Item:
File | Description | Size | Format | |
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LÓPEZ POYATOS ANA_4253520_assignsubmission_file_TFG-Lopez-Poyatos-Ana.pdf | 5.02 MB | Adobe PDF | View/Open |
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