Please use this identifier to cite or link to this item:
Title: Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World
Author: Polke, Markus
Kondoh, Yasuhiro
Wijsenbeek, Marlies
Cottin, Vincent
Walsh, Simon L. F.
Collard, Harold R.
Chaudhuri, Nazia
Avdeev, Sergey
Behr, Jürgen
Calligaro, Gregory
Corte, Tamera J.
Flaherty, Kevin
Funke Chambour, Manuela
Kolb, Martin
Krisam, Johannes
Maher, Toby M.
Molina Molina, María
Morais, Antonio
Moor, Catharina C.
Morisset, Julie
Pereira, Carlos
Quadrelli, Silvia
Selman, Moises
Tzouvelekis, Argyrios
Valenzuela, Claudia
Vancheri, Carlo
Vicens Zygmunt, Vanesa
Wälscher, Julia
Wuyts, Wim
Bendstrup, Elisabeth
Kreuter, Michael
Keywords: Fibrosi pulmonar
Pulmonary fibrosis
Issue Date: 27-Sep-2021
Publisher: Frontiers Media SA
Abstract: Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Material and Methods: Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians' institutions. Results: Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods. Conclusion: Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Medicine, 2021, vol. 8
Related resource:
ISSN: 2296-858X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
fmed-08-699644.pdf1.03 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons