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Title: Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial
Author: Laguna, Juan C.
Alegret, Marta
Cofán, Montserrat
Sánchez-Tainta, Ana
Díaz-López, Andrés
Martínez-González, Miguel A.
Sorlí, José V.
Salas-Salvadó, Jordi
Fitó, Montserrat
Alonso-Gómez, Ángel M.
Serra-Majem, Lluís
Lapetra, José
Fiol, Miquel
Gómez-gracia, Enrique
Pintó Sala, Xavier
Muñoz, Miguel A.
Castañer, Olga
Ramírez-sabio, Judith B.
Portu, José J.
Estruch, Ramón
Ros, Emilio
Keywords: Cuina (Sucre)
Cooking (Sugar)
Issue Date: 1-Aug-2021
Publisher: Elsevier BV
Abstract: Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 ± 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality.
Note: Reproducció del document publicat a:
It is part of: Clinical Nutrition, 2021, vol. 40, num. 10, p. 5269-5277
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ISSN: 0261-5614
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Medicina)

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