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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180960
Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial
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Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 ± 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality.
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LAGUNA, Juan c., ALEGRET, Marta, COFÁN, Montserrat, SÁNCHEZ-TAINTA, Ana, DÍAZ-LÓPEZ, Andrés, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SORLÍ, José v., SALAS-SALVADÓ, Jordi, FITÓ, Montserrat, ALONSO-GÓMEZ, Ángel m., SERRA-MAJEM, Lluís, LAPETRA, José, FIOL, Miquel, GÓMEZ-GRACIA, Enrique, PINTÓ SALA, Xavier, MUÑOZ PÉREZ, Miguel ángel, CASTAÑER, Olga, RAMÍREZ-SABIO, Judith b., PORTU, José j., ESTRUCH, Ramón, ROS, Emilio. Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial. _Clinical Nutrition_. 2021. Vol. 40, núm. 10, pàgs. 5269-5277. [consulta: 15 de febrer de 2026]. ISSN: 0261-5614. [Disponible a: https://hdl.handle.net/2445/180960]