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http://hdl.handle.net/2445/181054
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DC Field | Value | Language |
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dc.contributor.author | Pegueroles, Jordi | - |
dc.contributor.author | Pané, Adriana | - |
dc.contributor.author | Vilaplana, Eduard | - |
dc.contributor.author | Montal, Víctor | - |
dc.contributor.author | Bejanin, Alexandre | - |
dc.contributor.author | Videla, Laura | - |
dc.contributor.author | Carmona Iragui, María | - |
dc.contributor.author | Barroeta, Isabel | - |
dc.contributor.author | Ibarzabal, Ainitze | - |
dc.contributor.author | Casajoana, Anna | - |
dc.contributor.author | Alcolea, Daniel | - |
dc.contributor.author | Valldeneu, Silvia | - |
dc.contributor.author | Altuna, Miren | - |
dc.contributor.author | Hollanda Ramírez, Ana M. de | - |
dc.contributor.author | Vidal i Cortada, Josep | - |
dc.contributor.author | Ortega, Emilio | - |
dc.contributor.author | Osorio, Ricardo | - |
dc.contributor.author | Convit, Antonio | - |
dc.contributor.author | Blesa González, Rafael | - |
dc.contributor.author | Lleó Bisa, Alberto | - |
dc.contributor.author | Fortea Ormaechea, Juan | - |
dc.contributor.author | Jiménez, Amanda | - |
dc.contributor.author | Alzheimer's Disease Neuroimaging Initiative | - |
dc.date.accessioned | 2021-11-04T13:38:27Z | - |
dc.date.available | 2021-11-04T13:38:27Z | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 2352-8729 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181054 | - |
dc.description.abstract | Aims/hypothesis: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. Methods: We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). Results: We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. Conclusions/interpretation: In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/dad2.12052 | - |
dc.relation.ispartof | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, vol. 12, num. 1 | - |
dc.relation.uri | https://doi.org/10.1002/dad2.12052 | - |
dc.rights | cc by-nc-nd (c) Pegueroles, Jordi et al, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Demència | - |
dc.subject.other | Obesity | - |
dc.subject.other | Dementia | - |
dc.title | Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-11-04T12:11:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32743041 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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dad2.12052.pdf | 2.24 MB | Adobe PDF | View/Open |
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