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http://hdl.handle.net/2445/181126
Title: | Lower-limb lymphedema after sentinel lymph node biopsy in cervical cancer patients |
Author: | Cibula, David Borčinová, Martina Marnitz, Simone Jarkovský, Jiří Klát, Jaroslav Pilka, Radovan Ponce i Sebastià, Jordi Torné Bladé, Aureli Zapardiel, Ignacio Petiz, Almerinda Lay, Laura Sehnal, Borek Felsinger, Michal Arencibia Sánchez, Octavio Ka čák, Peter Zalewski, Kamil Presl, Jiri Palop-Moscardó, Alicia Tingulstad, Solveig Vergote, Ignace Redecha, Mikulá Frühauf, Filip Köhler, Christhardt Kocián, Roman |
Keywords: | Càncer Vèrtebres cervicals Limfoedema Biòpsia Cancer Cervical vertebrae Lymphedema Biopsy |
Issue Date: | 13-May-2021 |
Publisher: | MDPI |
Abstract: | Background: to prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND. Methods: a prospective study in 150 patients with stage IA1-IB2 cervical cancer treated by uterine surgery with bilateral SLN biopsy. Objective LLL assessments, based on limb volume increase (LVI) between pre- and postoperative measurements, and subjective patient-perceived swelling were conducted in six-month periods over 24-months post-surgery. Results: the cumulative incidence of LLL at 24 months was 17.3% for mild LLL (LVI 10-19%), 9.2% for moderate LLL (LVI 20-39%), while only one patient (0.7%) developed severe LLL (LVI > 40%). The median interval to LLL onset was nine months. Transient edema resolving without intervention within six months was reported in an additional 22% of patients. Subjective LLL was reported by 10.7% of patients, though only a weak and partial correlation between subjective-report and objective-LVI was found. No risk factor directly related to LLL development was identified. Conclusions: the replacement of standard PLND by bilateral SLN biopsy in the surgical treatment of cervical cancer does not eliminate the risk of mild to moderate LLL, which develops irrespective of the number of SLN removed. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers13102360 |
It is part of: | Cancers, 2021, vol. 13, num. 10, p. 2360 |
URI: | http://hdl.handle.net/2445/181126 |
Related resource: | https://doi.org/10.3390/cancers13102360 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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