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Title: Characterization of the endometrial MSC marker ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) in low- and high-grade endometrial carcinomas: loss of stromal expression in the invasive phenotypes
Author: Rodríguez-Martínez, Aitor
Trapero, Carla
Vidal, August
Piulats, Josep M.
Gómez de Aranda, Inmaculada
Sévigny, Jean
Fernández Montolí, Ma. Eulalia
Ponce i Sebastià, Jordi
Matias-Guiu, Xavier
Martín Satué, Mireia
Keywords: Càncer d'endometri
Endometrial cancer
Issue Date: 22-Apr-2021
Publisher: MDPI
Abstract: Ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) has been described in human non-pathological endometrium in both epithelial and stromal components without changes along the cycle. It was identified as a stromal marker of basalis. In the present study, we aimed to evaluate NTPDase2 distribution, using immunolabeling and in situ enzyme activity approaches, in endometrial carcinoma (EC) at different tumor grades. NTPDase2 was present in tumor epithelial EC cells, as in the non-pathological endometria, but the expression underwent changes in subcellular distribution and also tended to decrease with the tumor grade. In stroma, NTPDase2 was identified exclusively at the tumor-myometrial junction but this expression was lost in tumors of invasive phenotype. We have also identified in EC samples the presence of the perivascular population of endometrial mesenchymal stem cells (eMSCs) positive for sushi domain containing 2 (SUSD2) and for NTPDase2, already described in non-tumoral endometrium. Our results point to NTPDase2 as a histopathological marker of tumor invasion in EC, with diagnostic relevance especially in cases of EC coexisting with other endometrial disorders, such as adenomyosis, which occasionally hampers the assessment of tumor invasion parameters.
Note: Reproducció del document publicat a:
It is part of: Journal of Personalized Medicine, 2021, vol. 11, num. 5, p. 331
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ISSN: 2075-4426
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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