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http://hdl.handle.net/2445/181196
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DC Field | Value | Language |
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dc.contributor.author | Prunier, Chloé | - |
dc.contributor.author | Alay, Ania | - |
dc.contributor.author | Dijk, Michiel van | - |
dc.contributor.author | Ammerlaan, Kelly L. | - |
dc.contributor.author | Gelderen, Sharon van | - |
dc.contributor.author | Marvin, Dieuwke L. | - |
dc.contributor.author | Teunisse, Amina | - |
dc.contributor.author | Slieker, Roderick C. | - |
dc.contributor.author | Szuhai, Karoly | - |
dc.contributor.author | Jochemsen, A. G. | - |
dc.contributor.author | Solé, Xavier | - |
dc.contributor.author | Dijke, Peter ten | - |
dc.contributor.author | Ritsma, Laila | - |
dc.date.accessioned | 2021-11-11T09:37:16Z | - |
dc.date.available | 2021-11-11T09:37:16Z | - |
dc.date.issued | 2021-10-27 | - |
dc.identifier.issn | 2374-4677 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181196 | - |
dc.description.abstract | Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and reliable models. Here, we thoroughly characterize the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and/or in vitro, and assess if there is overlap between a dormant and a senescent phenotype. We show that D2.OR but not D2A1 cells become dormant in the liver of an immunocompetent model. In vitro, we show that D2.OR and ZR-75-1 cells in response to a 3D environment or serum-free conditions are growth-arrested in G1, of which a subpopulation resides in a 4NG1 state. The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41523-021-00347-0 | - |
dc.relation.ispartof | npj Breast Cancer, 2021, vol. 7, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41523-021-00347-0 | - |
dc.rights | cc by (c) Prunier, Chloé et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Cèl·lules canceroses | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Cancer cells | - |
dc.title | Breast cancer dormancy is associated with a 4NG1 state and not senescence | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-11-11T09:30:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34707097 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41523-021-00347-0.pdf | 1.47 MB | Adobe PDF | View/Open |
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