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Title: | Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer's Disease Hallmarks in SAMP8 Mice |
Author: | Rosell-Cardona, Cristina Griñán Ferré, Christian Pérez Bosque, Anna Polo Pozo, Francisco Javier Pallàs i Llibería, Mercè, 1964- Amat, Concepció Moretó, Miquel, 1950- Miró Martí, Ma. Lluïsa |
Keywords: | Malaltia d'Alzheimer Envelliment Suplements nutritius Alzheimer's disease Aging Dietary supplements |
Issue Date: | 1-Jul-2021 |
Publisher: | MDPI |
Abstract: | Alzheimer's disease (AD) is characterized by the aberrant processing of amyloid precursor protein (APP) and the accumulation of hyperphosphorylated tau, both of which are accompanied by neuroinflammation. Dietary supplementation with spray-dried porcine plasma (SDP) has anti-inflammatory effects in inflammation models. We investigated whether dietary supplementation with SDP prevents the neuropathological features of AD. The experiments were performed in 2- and 6-month-old SAMP8 mice fed a control diet, or a diet supplemented with 8% SDP, for 4 months. AD brain molecular markers were determined by Western blot and real-time PCR. Senescent mice showed reduced levels of p-GSK3β (Ser9) and an increase in p-CDK5, p-tau (Ser396), sAPPβ, and the concentration of Aβ40, (all p < 0.05). SDP prevented these effects of aging and reduced Bace1 levels (all p < 0.05). Senescence increased the expression of Mme1 and Ide1 and pro-inflammatory cytokines (Il-17 and Il-18; all p < 0.05); these changes were prevented by SDP supplementation. Moreover, SDP increased Tgf-β expression (p < 0.05). Furthermore, in aged mice, the gene expression levels of the microglial activation markers Trem2, Ym1, and Arg1 were increased, and SDP prevented these increases (all p < 0.05). Thus, dietary SDP might delay AD onset by reducing its hallmarks in senescent mice. View Full-Text Keywords: neuroinflammation; dietary supplementation; aging; plasma proteins; Alzheimer's disease; SAMP8 |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu13072369 |
It is part of: | Nutrients, 2021, vol. 13, num. 7 |
URI: | http://hdl.handle.net/2445/181198 |
Related resource: | https://doi.org/10.3390/nu13072369 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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