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http://hdl.handle.net/2445/181214
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DC Field | Value | Language |
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dc.contributor.author | Pinazo Durán, María Dolores | - |
dc.contributor.author | García Medina, Jose J. | - |
dc.contributor.author | Sanz-González, Silvia M. | - |
dc.contributor.author | O'Connor, José Enrique | - |
dc.contributor.author | Casaroli Marano, Ricardo Pedro | - |
dc.contributor.author | Valero Velló, Mar | - |
dc.contributor.author | López Gálvez, María Isabel | - |
dc.contributor.author | Peris Martínez, Cristina | - |
dc.contributor.author | Zanón Moreno, Vicente | - |
dc.contributor.author | Díaz Llopis, Manuel | - |
dc.date.accessioned | 2021-11-11T12:43:43Z | - |
dc.date.available | 2021-11-11T12:43:43Z | - |
dc.date.issued | 2021-04-19 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181214 | - |
dc.description.abstract | The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (-) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10-5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10-4), and TNFα (p = 2 × 10-4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10-7) and IL-6 (p = 3 × 10-6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision los | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/diagnostics11040724 | - |
dc.relation.ispartof | Diagnostics, 2021, vol. 11, num. 724 | - |
dc.relation.uri | https://doi.org/10.3390/diagnostics11040724 | - |
dc.rights | cc-by (c) Pinazo Durán, María Dolores et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Uveïtis | - |
dc.subject.classification | Triglicèrids | - |
dc.subject.classification | Àcids grassos omega-3 | - |
dc.subject.other | Uveitis | - |
dc.subject.other | Triglycerides | - |
dc.subject.other | Omega-3 fatty acids | - |
dc.title | Signature of circulating biomarkers in recurrent non-infectious anterior uveitis. Immunomodulatory effects of DHA-triglyceride. A pilot study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711737 | - |
dc.date.updated | 2021-11-11T12:43:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33921773 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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711737.pdf | 19.12 MB | Adobe PDF | View/Open |
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