Please use this identifier to cite or link to this item:
Title: Can the Addition of Maintenance Electroconvulsive Therapy to Pharmacotherapy Improve Relapse Prevention in Severe Major Depressive Disorder? A Randomized Controlled Trial
Author: Martínez Amorós, Erika
Cardoner, N. (Narcís)
Gálvez, Verònica
Arriba Arnau, Aida de
Soria, Virginia
Palao Vidal, Diego J.
Menchón Magriñá, José Manuel
Urretavizcaya Sarachaga, Mikel
Keywords: Depressió psíquica
Medicina preventiva
Assaigs clínics de medicaments
Mental depression
Preventive medicine
Drug testing
Issue Date: 11-Oct-2021
Publisher: MDPI AG
Abstract: Few systematic evaluations have been performed of the efficacy of electroconvulsive therapy (ECT) as a relapse prevention strategy in major depressive disorder (MDD). This is a single-blind, multicenter, randomized controlled trial to compare the efficacy and tolerability of pharmacotherapy plus maintenance ECT (M-Pharm/ECT) versus pharmacotherapy alone (M-Pharm) in the prevention of MDD relapse. Subjects with MDD who had remitted with bilateral acute ECT (n = 37) were randomly assigned to receive M-Pharm/ECT (n = 19, 14 treatments) or M-Pharm (n = 18) for nine months. The subjects were followed up for 15 months. The main outcome was relapse of depression, defined as a score of 18 or more on the Hamilton Depression Rating Scale. At nine months, 35% of the subjects treated with M-Pharm/ECT relapsed as compared with 61% of the patients treated with M-Pharm. No statistically significant differences between groups were indicated by either Kaplan-Meier or Cox proportional hazards regression analyses. The subjects without psychotic features were at higher risk of relapse. There were no statistically significant differences in the MMSE scores of the two groups at the end of the study. Further studies are needed to better define the indications for M-ECT in order to improve its efficacy as a relapse prevention strategy.
Note: Reproducció del document publicat a:
It is part of: Brain Sciences, 2021, vol. 11, num. 10, p. 1340
Related resource:
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
brainsci-11-01340-v2.pdf1.93 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons