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http://hdl.handle.net/2445/181361
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DC Field | Value | Language |
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dc.contributor.author | Muñoz Gómez, Ana | - |
dc.contributor.author | Fernández Cruz, Ana | - |
dc.contributor.author | Lavilla Olleros, Cristina | - |
dc.contributor.author | Giner Galvañ, Vicente | - |
dc.contributor.author | Ausín García, Cristina | - |
dc.contributor.author | Wikman, Philip | - |
dc.contributor.author | Bendala Estrada, Alejandro David | - |
dc.contributor.author | Vargas Núñez, Juan Antonio | - |
dc.contributor.author | Rubio Rivas, Manuel | - |
dc.contributor.author | Laureiro, Jaime | - |
dc.contributor.author | Fernández Bermúdez, Daniel | - |
dc.contributor.author | Buonaiuto, Verónica A. | - |
dc.contributor.author | Arenas de Larriva, Antonio P. | - |
dc.contributor.author | Pascual Pérez, Maria | - |
dc.contributor.author | Alcalá Pedrajas, José Nicolás | - |
dc.contributor.author | Labirua-Iturburu Ruiz, Ane | - |
dc.contributor.author | Hernández Milián, Almudena | - |
dc.contributor.author | Gómez del Mazo, Marta | - |
dc.contributor.author | Antequera, Beatriz | - |
dc.contributor.author | Mella Pérez, Carmen | - |
dc.contributor.author | Navas Alcántara, María | - |
dc.contributor.author | Soto Delgado, Juan F. | - |
dc.contributor.author | Gámez Mancera, Rosa M. | - |
dc.contributor.author | Sardiña González, Cristina | - |
dc.contributor.author | Meijide Míguez, Héctor | - |
dc.contributor.author | Ramos Rincón, José Manuel | - |
dc.contributor.author | Gómez Huelgas, Ricardo | - |
dc.contributor.author | On Behalf Of The Semi-COVID19 Network | - |
dc.date.accessioned | 2021-11-18T14:05:09Z | - |
dc.date.available | 2021-11-18T14:05:09Z | - |
dc.date.issued | 2021-10-13 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181361 | - |
dc.description.abstract | We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242]; p = 0.0001); however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%; OR 0.564 [95% confidence interval; 0.503 to 0.633]; p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10204678 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 20, p. 4678 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10204678 | - |
dc.rights | cc-by (c) Muñoz-Gómez, Ana et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Cortisona | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Cortisone | - |
dc.subject.other | Mortality | - |
dc.title | Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-11-18T09:47:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34682801 | - |
dc.identifier.pmid | 34682801 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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jcm-10-04678-v2.pdf | 270.24 kB | Adobe PDF | View/Open |
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