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Title: Stabilization by nano spray dryer of pioglitazone polymeric nanosystems: development, in vivo, ex vivo and synchrotron analysis
Author: Silva Abreu, Marcelle
Miralles, Esther
Kamma-Lorger, Christina S.
Espina García, Marta
García López, María Luisa
Calpena Campmany, Ana Cristina
Keywords: Sistemes d'alliberament de medicaments
Farmacologia ocular
Agents antiinflamatoris
Drug delivery systems
Ocular pharmacology
Antiinflammatory agents
Issue Date: 20-Oct-2021
Publisher: MDPI
Abstract: Pioglitazone-loaded PLGA-PEG nanoparticles (NPs) were stabilized by the spray drying technique as an alternative to the treatment of ocular inflammatory disorders. Pioglitazone-NPs were developed and characterized physiochemically. Interaction studies, biopharmaceutical behavior, ex vivo corneal and scleral permeation, and in vivo bioavailability evaluations were conducted. Fibrillar diameter and interfibrillar corneal spacing of collagen was analyzed by synchrotron X-ray scattering techniques and stability studies at 4 °C and was carried out before and after the spray drying process. NPs showed physicochemical characteristics suitable for ocular administration. The release was sustained up to 46 h after drying; ex vivo corneal and scleral permeation profiles of pioglitazone-NPs before and after drying demonstrated higher retention and permeation through cornea than sclera. These results were correlated with an in vivo bioavailability study. Small-angle X-ray scattering (SAXS) analysis did not show a significant difference in the organization of the corneal collagen after the treatment with pioglitazone-NPs before and after the drying process, regarding the negative control. The stabilization process by Nano Spray Dryer B-90 was shown to be useful in preserving the activity of pioglitazone inside the NPs, maintaining their physicochemical characteristics, in vivo bioavailability, and non-damage to corneal collagen function after SAXS analysis was observed. Keywords: PLGA-PEG; pioglitazone; nanoparticles; spray drying; cornea; synchrotron; SAXS
Note: Reproducció del document publicat a:
It is part of: Pharmaceutics, 2021, vol. 13
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ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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